A comparison of the effects of isoflurane and ketamine anesthesia on auditory brainstem response (ABR) thresholds in rats

被引:54
|
作者
Ruebhausen, M. R. [1 ]
Brozoski, T. J. [1 ]
Bauer, C. A. [1 ]
机构
[1] So Illinois Univ, Sch Med, Div Otolaryngol Head & Neck Surg, Springfield, IL 62702 USA
关键词
CEREBRAL BLOOD-FLOW; HALOTHANE; MICE;
D O I
10.1016/j.heares.2012.04.005
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
The auditory brainstem response (ABR) is an acoustically evoked potential commonly used to determine hearing sensitivity in laboratory animals. Both isoflurane and ketamine/xylazine anesthesia are commonly used to immobilize animals during ABR procedures. Hearing threshold determination is often the primary interest. Although a number of studies have examined the effect of different anesthetics on evoked potential waveforms and growth functions, none have directly compared their effect on ABR hearing threshold estimates. The present study used a within-subject comparison and typical threshold criteria, to examine the effect of isoflurane and ketamine/xylazine on ABR thresholds for clicks and pure-tone stimuli extending from 8 to 32 kHz. At comparable physiological doses, hearing thresholds obtained with isoflurane (1.7% in O-2) were on average elevated across a broad frequency range by greater than 27 dB compared to ketamine/xylazine (ketamine HCl, 50 mg/kg: xylazine, 9 mg/kg). This highly significant threshold effect (F-1,F-6 = 158.3403, p = 3.51 x 10(-22)) demonstrates a substantial difference between general anesthetics on auditory brainstem sensitivity. Potential mechanisms and implications for ABR threshold determination under anesthesia are discussed. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:25 / 29
页数:5
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