One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

被引：3

作者：

Sumino, Shuhei ^{[1
]}

Fusano, Akira ^{[1
]}

Okai, Hiroyuki ^{[1
]}

Fukuyama, Takahide ^{[1
]}

Ryu, Ilhyong ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Grad Sch Sci, Dept Chem, Sakai, Osaka 5998531, Japan

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷

关键词：

alkyl bromide; carbon monoxide; cyanohydrin; ethyl cyanoformate; multicomponent; radical reaction; O-METHOXYCARBONYL CYANOHYDRIN; PROTECTIVE GROUP; HYDROXYMETHYLATION; CO; CARBONYLATION; CONVENIENT; ALDEHYDES; MONOXIDE; KETONES; HYDRIDES;

D O I：

10.3762/bjoc.10.12

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.

引用

页码：150 / 154

页数：5

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