One-pot synthesis of cyanohydrin derivatives from alkyl bromides via incorporation of two one-carbon components by consecutive radical/ionic reactions

被引：3
|
作者：
Sumino, Shuhei [1 ]
Fusano, Akira [1 ]
Okai, Hiroyuki [1 ]
Fukuyama, Takahide [1 ]
Ryu, Ilhyong [1 ]
机构：
[1] Osaka Prefecture Univ, Grad Sch Sci, Dept Chem, Sakai, Osaka 5998531, Japan
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷
关键词：
alkyl bromide; carbon monoxide; cyanohydrin; ethyl cyanoformate; multicomponent; radical reaction; O-METHOXYCARBONYL CYANOHYDRIN; PROTECTIVE GROUP; HYDROXYMETHYLATION; CO; CARBONYLATION; CONVENIENT; ALDEHYDES; MONOXIDE; KETONES; HYDRIDES;
D O I：
10.3762/bjoc.10.12
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The consecutive radical/ionic reaction consisting of radical formylation of alkyl bromides and nucleophilic addition of a cyanide ion was investigated, which gave moderate to good yields of cyanohydrin derivatives in one-pot.
引用
收藏
页码：150 / 154
页数：5
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