Organocatalytic Domino Michael/cyclization for the synthesis of highly substituted 4, 5-dihydrothiophenes

被引：9
|
作者：
Ding, Chen-Hao [1 ]
Dong, Jian-Lian [1 ]
Yu, Li-Si-Han [1 ]
Xie, Jian-Wu [1 ]
机构：
[1] Zhejiang Normal Univ, Dept Chem & Life Sci, Jinhua 321004, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Dihydrothiophenes; Organocatalysis; 1,3-Dicarbonyl compounds; Thioamides; Nitrostyrenes; MEDICINE SALACIA-RETICULATA; SULFONIUM SULFATE STRUCTURE; ENANTIOSELECTIVE SYNTHESIS; 2-HALO-1,3-DICARBONYL COMPOUNDS; STEREOCONTROLLED SYNTHESIS; ORGANIC SEMICONDUCTORS; ASYMMETRIC-SYNTHESIS; CHIRAL SULFIDES; TETRAHYDROTHIOPHENES; YLIDES;
D O I：
10.1016/j.cclet.2017.08.048
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient organocatalytic asymmetric a formal thio[3+2]-cyclization of acyclic thioamides with (E)alpha-nitrostyrenes. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：517 / 520
页数：4
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