Organocatalytic Domino Michael/cyclization for the synthesis of highly substituted 4, 5-dihydrothiophenes

被引：9

作者：

Ding, Chen-Hao ^{[1
]}

Dong, Jian-Lian ^{[1
]}

Yu, Li-Si-Han ^{[1
]}

Xie, Jian-Wu ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Dept Chem & Life Sci, Jinhua 321004, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Dihydrothiophenes; Organocatalysis; 1,3-Dicarbonyl compounds; Thioamides; Nitrostyrenes; MEDICINE SALACIA-RETICULATA; SULFONIUM SULFATE STRUCTURE; ENANTIOSELECTIVE SYNTHESIS; 2-HALO-1,3-DICARBONYL COMPOUNDS; STEREOCONTROLLED SYNTHESIS; ORGANIC SEMICONDUCTORS; ASYMMETRIC-SYNTHESIS; CHIRAL SULFIDES; TETRAHYDROTHIOPHENES; YLIDES;

D O I：

10.1016/j.cclet.2017.08.048

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient organocatalytic asymmetric a formal thio[3+2]-cyclization of acyclic thioamides with (E)alpha-nitrostyrenes. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：517 / 520

页数：4

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