Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli

被引：19

作者：

Zhao, XL ^{[1
]}

Malik, M ^{[1
]}

Chan, N ^{[1
]}

Drlica-Wagner, A ^{[1
]}

Wang, JY ^{[1
]}

Li, XY ^{[1
]}

Drlica, K ^{[1
]}

机构：

[1] Publ Hlth Res Inst, Newark, NJ 07103 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 01期

关键词：

D O I：

10.1128/AAC.50.1.362-364.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.

引用

页码：362 / 364

页数：3

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