Lethal action of quinolones against a temperature-sensitive dnaB replication mutant of Escherichia coli

被引：19
|
作者：
Zhao, XL [1 ]
Malik, M [1 ]
Chan, N [1 ]
Drlica-Wagner, A [1 ]
Wang, JY [1 ]
Li, XY [1 ]
Drlica, K [1 ]
机构：
[1] Publ Hlth Res Inst, Newark, NJ 07103 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 01期
关键词：
D O I：
10.1128/AAC.50.1.362-364.2006
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Inhibition of DNA replication in an Escherichia coli dnaB-22 mutant failed to block quinolone-mediated lethality. Inhibition of protein synthesis by chloramphenicol inhibited nalidixic acid lethality and, to a lesser extent, ciprofloxacin lethality in both dnaB-22 and wild-type cells. Thus, major features of quinolone-mediated lethality do not depend on ongoing replication.
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页码：362 / 364
页数：3
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