New Dammarane-Type Saponins from Gynostemma pentaphyllum

被引：14
|
作者：
Chen, Po-Yen [1 ,2 ,3 ]
Chang, Chih-Chao [1 ]
Huang, Hui-Chi [4 ]
Zhang, Li-Jie [1 ]
Liaw, Chia-Ching [5 ]
Lin, Yu-Chi [1 ]
Nham-Linh Nguyen [1 ,6 ]
Thanh-Hoa Vo [1 ,6 ]
Cheng, Yung-Yi [7 ,8 ]
Morris-Natschke, Susan L. [7 ]
Lee, Kuo-Hsiung [7 ,8 ]
Kuo, Yao-Haur [1 ,6 ,9 ]
机构：
[1] Natl Res Inst Chinese Med, Div Chinese Mat Med Dev, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Dept Life Sci, Taipei 112, Taiwan
[3] Natl Yang Ming Univ, Inst Genome Sci, Taipei 112, Taiwan
[4] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan
[5] Starsci Biotech Co Ltd, Dept Res & Dev, Taipei 112, Taiwan
[6] Taipei Med Univ, Coll Pharm, PhD Program Clin Drug Dev Chinese Herbal Med, Taipei 11031, Taiwan
[7] Univ N Carolina, Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA
[8] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan
[9] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung 404, Taiwan
来源：
MOLECULES | 2019年 / 24卷 / 07期
关键词：
Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity; CUCURBITACEAE PLANTS; TRITERPENE SAPONINS; FLAVONOIDS; GLYCOSIDES; ANTIPROLIFERATION; CONSTITUENTS; GYPENOSIDES; POLYSACCHARIDES; MAKINO; GALLS;
D O I：
10.3390/molecules24071375
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six new dammarane-type saponins, gypenosides CP1-6 (1-6), along with 19 known compounds 7-25, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).
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页数：13
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