New Dammarane-Type Saponins from Gynostemma pentaphyllum

被引：14

作者：

Chen, Po-Yen ^{[1
,2
,3
]}

Chang, Chih-Chao ^{[1
]}

Huang, Hui-Chi ^{[4
]}

Zhang, Li-Jie ^{[1
]}

Liaw, Chia-Ching ^{[5
]}

Lin, Yu-Chi ^{[1
]}

Nham-Linh Nguyen ^{[1
,6
]}

Thanh-Hoa Vo ^{[1
,6
]}

Cheng, Yung-Yi ^{[7
,8
]}

Morris-Natschke, Susan L. ^{[7
]}

Lee, Kuo-Hsiung ^{[7
,8
]}

Kuo, Yao-Haur ^{[1
,6
,9
]}

机构：

[1] Natl Res Inst Chinese Med, Div Chinese Mat Med Dev, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Dept Life Sci, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Genome Sci, Taipei 112, Taiwan

[4] China Med Univ, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 404, Taiwan

[5] Starsci Biotech Co Ltd, Dept Res & Dev, Taipei 112, Taiwan

[6] Taipei Med Univ, Coll Pharm, PhD Program Clin Drug Dev Chinese Herbal Med, Taipei 11031, Taiwan

[7] Univ N Carolina, Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA

[8] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan

[9] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung 404, Taiwan

来源：

MOLECULES | 2019年 / 24卷 / 07期

关键词：

Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity; CUCURBITACEAE PLANTS; TRITERPENE SAPONINS; FLAVONOIDS; GLYCOSIDES; ANTIPROLIFERATION; CONSTITUENTS; GYPENOSIDES; POLYSACCHARIDES; MAKINO; GALLS;

D O I：

10.3390/molecules24071375

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new dammarane-type saponins, gypenosides CP1-6 (1-6), along with 19 known compounds 7-25, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).

引用

页数：13

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