Facile Synthesis of 4-Substituted-2-quinolinone-3-carboxylic Acid Ethyl Esters

被引：0
|
作者：
Zhang, Lijuan [1 ]
Luo, Yu [1 ]
Yu, Shanbao [1 ]
Lu, Wei [1 ,2 ]
机构：
[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China
[2] E China Normal Univ, Inst Drug Discovery & Dev, iAIR, Shanghai 200062, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2012年 / 49卷 / 05期
关键词：
KINASE INHIBITORS; ACTIVATION; DESIGN;
D O I：
10.1002/jhet.967
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient route for the synthesis of 4-substituted-2-quinolinone-3-carboxylic acid ethyl esters has been developed through Suzuki or Sonogashira reactions. The advantages of the method include high yields, operational simplicity, and suitability for medicinal modification of 4-substituted quinolinones and their derivatives.
引用
收藏
页码：1254 / 1256
页数：3
相关论文
共 50 条
  • [21] Synthesis and Antiviral Activity of Substituted 2,4-bis-aminomethyl-5-hydroxy-1H-indole-3-carboxylic Acid Ethyl Esters and their Derivatives
    A. V. Ivashchenko
    P. M. Yamanushkin
    O. D. Mit’kin
    V. M. Kisil’
    O. M. Korzinov
    V. Yu. Vedenskii
    I. A. Leneva
    E. A. Bulanova
    V. V. Bychko
    I. M. Okun’
    A. A. Ivashchenko
    Ya. A. Ivanenkov
    Pharmaceutical Chemistry Journal, 2014, 48 : 569 - 581
  • [22] Synthesis and Antiviral Activity of Substituted 2,4-bis-aminomethyl-5-hydroxy-1H-indole-3-carboxylic Acid Ethyl Esters and their Derivatives
    Ivashchenko, A. V.
    Yamanushkin, P. M.
    Mit'kin, O. D.
    Kisil', V. M.
    Korzinov, O. M.
    Vedenskii, V. Yu
    Leneva, I. A.
    Bulanova, E. A.
    Bychko, V. V.
    Okun', I. M.
    Ivashchenko, A. A.
    Ivanenkov, Ya A.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2014, 48 (09) : 569 - 581
  • [23] Synthesis of 4,5-Dichloroisothiazole-3-carboxylic Acid Amides and Esters
    N. I. Nechai
    E. A. Dikusar
    V. I. Potkin
    R. V. Kaberdin
    Russian Journal of Organic Chemistry, 2004, 40 : 1009 - 1014
  • [24] Synthesis of 4,5-dichloroisothiazole-3-carboxylic acid amides and esters
    Nechai, NI
    Dikusar, EA
    Potkin, VI
    Kaberdin, RV
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2004, 40 (07) : 1009 - 1014
  • [25] Synthesis of Novel Triazolyl-substituted Carboxylic Acid Esters and Their Aminolysis
    Vikrishchuk, N. I.
    Popov, L. D.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 55 (02) : 234 - 240
  • [26] Synthesis of Novel Triazolyl-substituted Carboxylic Acid Esters and Their Aminolysis
    N. I. Vikrishchuk
    L. D. Popov
    Russian Journal of Organic Chemistry, 2019, 55 : 234 - 240
  • [27] FACILE SYNTHESIS OF 2-ETHYL-3-QUINOLINECARBOXYLIC ACID HYDROCHLORIDE
    McNaughton, Brian R.
    Miller, Benjamin L.
    ORGANIC SYNTHESES, 2008, 85 : 27 - +
  • [28] Facile synthesis of α-substituted acrylate esters
    Hin, B
    Majer, P
    Tsukamoto, T
    JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (21): : 7365 - 7368
  • [29] ORGN 383-Synthesis of substituted benzofuran-2-carboxylic acid ethyl ester
    Martinez Troncoso, Luisa
    Yamaguchi, Kenneth
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [30] Efficient synthesis of 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters
    Murphy, Douglas E.
    Dragovich, Peter S.
    Ayida, Benjamin K.
    Bertolini, Thomas M.
    Li, Lian-Sheng
    Ruebsam, Frank
    Stankovic, Nebojsa S.
    Sun, Zhongxiang
    Zhao, Jingjing
    Zhou, Yuefen
    TETRAHEDRON LETTERS, 2008, 49 (05) : 811 - 815
12345