The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

被引：21
|
作者：
Cody, WL [1 ]
Cai, CM
Doherty, AM
Edmunds, JJ
He, JX
Narasimhan, LS
Plummer, JS
Rapundalo, ST
Rubin, JR
Van Huis, CA
St-Denis, Y
Winocour, PD
Siddiqui, MA
机构：
[1] Div Warner Lambert Co, Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA
[2] BioChem Pharma Inc, Laval, PQ H7V 4A7, Canada
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期
关键词：
D O I：
10.1016/S0960-894X(99)00418-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Utilizing X-ray crystallography and molecular modeling, highly potent and selective peptidomimetic thrombin inhibitors have been designed containing a rigid piperazinedione template. The synthesis and biological activity of these compounds will be described. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2497 / 2502
页数：6
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