The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: Part 1

被引：21

作者：

Cody, WL ^{[1
]}

Cai, CM

Doherty, AM

Edmunds, JJ

He, JX

Narasimhan, LS

Plummer, JS

Rapundalo, ST

Rubin, JR

Van Huis, CA

St-Denis, Y

Winocour, PD

Siddiqui, MA

机构：

[1] Div Warner Lambert Co, Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA

[2] BioChem Pharma Inc, Laval, PQ H7V 4A7, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(99)00418-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Utilizing X-ray crystallography and molecular modeling, highly potent and selective peptidomimetic thrombin inhibitors have been designed containing a rigid piperazinedione template. The synthesis and biological activity of these compounds will be described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2497 / 2502

页数：6

共 50 条

[21] Rational Design of Potent, Small, Synthetic Allosteric Inhibitors of Thrombin
Sidhu, Preetpal Singh
Liang, Aiye
Mehta, Akul Y.
Aziz, May H. Abdel
Zhou, Qibing
Desai, Umesh R.
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (15) : 5522 - 5531
[22] Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors
Short, Kevin M.
Estiarte, M. Angels
Pham, Son M.
Williams, David C.
Igoudin, Lev
Dash, Subhadra
Sandoval, Nichole
Datta, Anirban
Pozzi, Nicola
Di Cera, Enrico
Kita, David B.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 246
[23] Strategies for the design of potent and selective kinase inhibitors
McInnes, C
Fischer, PM
CURRENT PHARMACEUTICAL DESIGN, 2005, 11 (14) : 1845 - 1863
[24] Design and Synthesis of Potent, Selective Inhibitors of Matriptase
Colombo, Eloic
Desilets, Antoine
Duchene, Dominic
Chagnon, Felix
Najmanovich, Rafael
Leduc, Richard
Marsault, Eric
ACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (07): : 530 - 534
[25] Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1
Lorthiois, E
Bernardelli, P
Vergne, F
Oliveira, C
Mafroud, AK
Proust, E
Heuze, L
Moreau, F
Idrissi, M
Tertre, A
Bertin, B
Coupe, M
Wrigglesworth, R
Descours, A
Soulard, P
Berna, P
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (18) : 4623 - 4626
[26] De novo design of potent non-peptide thrombin inhibitors
Bohm, HJ
Banner, DW
Weber, L
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U689 - U689
[27] Structure-based design of novel potent nonpeptide thrombin inhibitors
Hauel, NH
Nar, H
Priepke, H
Ries, U
Stassen, JM
Wienen, W
JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (09) : 1757 - 1766
[28] Structure-Based Design of Potent and Selective CK1γ Inhibitors
Huang, Hongbing
Acquaviva, Lisa
Berry, Virginia
Bregman, Howard
Chakka, Nagasree
O'Connor, Anne
DiMauro, Erin F.
Dovey, Jennifer
Epstein, Oleg
Grubinska, Barbara
Goldstein, Jon
Gunaydin, Hakan
Hua, Zihao
Huang, Xin
Huang, Liyue
Human, Jason
Long, Alex
Newcomb, John
Patel, Vinod F.
Saffran, Doug
Serafino, Randy
Schneider, Steve
Strathdee, Craig
Tang, Jin
Turci, Susan
White, Ryan
Yu, Violeta
Zhao, Huilin
Wilson, Cindy
Martin, Matthew W.
ACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (12): : 1059 - 1064
[29] Design and synthesis of highly potent and selective protein geranylgeranyltransferase-1 inhibitors
Pusateri, EE
Carrico, D
Peng, HR
Sebti, S
Hamilton, AD
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U160 - U160
[30] Structure and design of potent and selective cathepsin K inhibitors
Yamashita, DS
Smith, WW
Zhao, BG
Janson, CA
Tomaszek, TA
Bossard, MJ
Levy, MA
Oh, HJ
Carr, TJ
Thompson, SK
Ijames, CF
Carr, SA
McQueney, M
DAlessio, KJ
Amegadzie, BY
Hanning, CR
AbdelMeguid, S
DesJarlais, RL
Gleason, JG
Veber, DF
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (46) : 11351 - 11352

← 1 2 3 4 5 →