Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

被引：6

作者：

Al Sheikha, Dima ^{[1
]}

Wilkinson, Brendan L. ^{[1
]}

Santhakumar, Gajan ^{[1
]}

Thaysen-Andersen, Morten ^{[2
]}

Payne, Richard J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] Macquarie Univ, Dept Chem & Biomol Sci, Sydney, NSW 2109, Australia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 36期

关键词：

KINETICALLY CONTROLLED LIGATION; CONVERGENT CHEMICAL-SYNTHESIS; CYSTEINE-FREE PEPTIDE; T-CELL EPITOPE; GLYCOPEPTIDE ANTIGENS; ASSISTED THIOESTERIFICATION; ANTITUMOR VACCINES; INDUCTION; PROTEINS; ACYL;

D O I：

10.1039/c3ob41363b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N -> S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8-9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.

引用

页码：6090 / 6096

页数：7

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