Synthesis of homogeneous MUC1 oligomers via a bi-directional ligation strategy

被引：6

作者：

Al Sheikha, Dima ^{[1
]}

Wilkinson, Brendan L. ^{[1
]}

Santhakumar, Gajan ^{[1
]}

Thaysen-Andersen, Morten ^{[2
]}

Payne, Richard J. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

[2] Macquarie Univ, Dept Chem & Biomol Sci, Sydney, NSW 2109, Australia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2013年 / 11卷 / 36期

关键词：

KINETICALLY CONTROLLED LIGATION; CONVERGENT CHEMICAL-SYNTHESIS; CYSTEINE-FREE PEPTIDE; T-CELL EPITOPE; GLYCOPEPTIDE ANTIGENS; ASSISTED THIOESTERIFICATION; ANTITUMOR VACCINES; INDUCTION; PROTEINS; ACYL;

D O I：

10.1039/c3ob41363b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient synthesis of homogeneous MUC1 peptide oligomers using sequential ligation reactions in the N-to-C and C-to-N directions is reported. The bi-directional ligation strategy makes use of thioester formation via N -> S acyl shift chemistry in combination with peptide ligation reactions and was used to prepare a library of peptide oligomers ranging in molecular mass from 3.8-9.4 kDa, comprised of between 2 and 5 repeats of the MUC1 variable number tandem repeat sequence.

引用

页码：6090 / 6096

页数：7

共 50 条

[21] Operating Strategy for Bi-directional LLC Resonant Converter with Seamless Operation
Abe, Seiya
Zaitsu, Toshiyuki
Yamamoto, Junichi
Ninomiya, Tamotsu
2014 INTERNATIONAL POWER ELECTRONICS CONFERENCE (IPEC-HIROSHIMA 2014 - ECCE-ASIA), 2014, : 1179 - 1184
[22] Rapid bi-directional synthesis of oligo(1,4-phenylene ethynylene)s
Huang, SL
Tour, JM
TETRAHEDRON LETTERS, 1999, 40 (17) : 3347 - 3350
[23] MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1
Rahn, JJ
Shen, Q
Mah, BK
Hugh, JC
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (28) : 29386 - 29390
[24] Bi-directional synthesis of 4-bit reversible circuits
Yang, Guowu
Song, Xiaoyu
Hung, William N. N.
Perkowski, Marek A.
COMPUTER JOURNAL, 2008, 51 (02): : 207 - 215
[25] Differential Compound Prioritization via Bi-Directional Selectivity Push with Power
Liu, Junfeng
Ning, Xia
ACM-BCB' 2017: PROCEEDINGS OF THE 8TH ACM INTERNATIONAL CONFERENCE ON BIOINFORMATICS, COMPUTATIONAL BIOLOGY,AND HEALTH INFORMATICS, 2017, : 394 - 399
[26] Bi-directional Synthesis of Pre- and Post-contrast MRI via Guided Feature Disentanglement
Xue, Yuan
Dewey, Blake E.
Zuo, Lianrui
Han, Shuo
Carass, Aaron
Duan, Peiyu
Remedios, Samuel W.
Pham, Dzung L.
Saidha, Shiv
Calabresi, Peter A.
Prince, Jerry L.
SIMULATION AND SYNTHESIS IN MEDICAL IMAGING, SASHIMI 2022, 2022, 13570 : 55 - 65
[27] Identification of a novel gene linked to parkin via a bi-directional promoter
West, AB
Lockhart, PJ
O'Farell, C
Farrer, MJ
JOURNAL OF MOLECULAR BIOLOGY, 2003, 326 (01) : 11 - 19
[28] Contextual sentiment embeddings via bi-directional GRU language model
Wang, Jin
Zhang, You
Yu, Liang-Chih
Zhang, Xuejie
KNOWLEDGE-BASED SYSTEMS, 2022, 235
[29] High Throughput Short Read Alignment via Bi-directional BWT
Lam, T. W.
Li, Ruiqiang
Tam, Alan
Wong, Simon
Wu, Edward
Yiu, S. M.
2009 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE, 2009, : 31 - +
[30] Pedestrian Detection via Bi-directional Multi-scale Analysis
Duan, Zhenyu
Lan, Jinpeng
Xu, Yi
Ni, Bingbing
Zhuang, Lixue
Yang, Xiaokang
PROCEEDINGS OF THE 2017 ACM MULTIMEDIA CONFERENCE (MM'17), 2017, : 1023 - 1031

← 1 2 3 4 5 →