Hepatitis C Viral Kinetics The Past, Present, and Future

被引：21

作者：

Chatterjee, Anushree ^{[1
,2
]}

Smith, Patrick F. ^{[3
]}

Perelson, Alan S. ^{[1
]}

机构：

[1] Los Alamos Natl Lab, Theoret Biol & Biophys, Los Alamos, NM 87545 USA

[2] Los Alamos Natl Lab, Ctr Nonlinear Studies, Los Alamos, NM 87545 USA

[3] Roche, Clin Pharmacol Pharma Res & Early Dev, Nutley, NJ USA

来源：

CLINICS IN LIVER DISEASE | 2013年 / 17卷 / 01期

关键词：

Mathematical modeling; Viral kinetics; Direct-acting antiviral agents; Protease inhibitors; Hepatitis C virus; DYNAMICS IN-VIVO; POLYMERASE INHIBITOR; ANTIVIRAL ACTIVITY; PROTEASE INHIBITORS; VIRUS-REPLICATION; TREATMENT-NAIVE; NONNUCLEOSIDE POLYMERASE; RESISTANCE MUTATIONS; ALPHA-INTERFERON; WILD-TYPE;

D O I：

10.1016/j.cld.2012.09.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to extend previous models so as to understand, characterize, and compare various new HCV treatment regimens. Here we review recent modeling efforts in this direction.

引用

页码：13 / +

页数：15

共 50 条

[41] Hepatitis C: Viral kinetics - Reply
Lam, NP
Neumann, AU
Perelson, AS
Layden, TJ
HEPATOLOGY, 1997, 26 (06) : 1692 - 1693
[42] Hepatitis B Virus: The Past, The Present, and The Future Preface
Hassanein, Tarek I.
CLINICS IN LIVER DISEASE, 2016, 20 (04) : IX - X
[43] Treatment of severe alcoholic hepatitis: past, present and future
Lanthier, Nicolas
Starkel, Peter
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2017, 47 (07) : 531 - 539
[44] HEPATITIS-B VACCINES - PAST, PRESENT, AND FUTURE
DESMYTER, J
POSTGRADUATE MEDICAL JOURNAL, 1987, 63 : 57 - 57
[45] Laboratory diagnosis of viral hepatitis in China: The present and the future
Wen, YM
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2001, 39 (12) : 1183 - 1189
[46] THERMAL-ANALYSIS KINETICS - PAST, PRESENT AND FUTURE
FLYNN, JH
THERMOCHIMICA ACTA, 1992, 203 : 519 - 526
[47] Bovine viral vaccines, diagnostics, and eradication: Past, present, and future
van Oirschot, JT
ADVANCES IN VETERINARY MEDICINE, VOL 41: VETERINARY VACCINES AND DIAGNOSTICS, 1999, 41 : 197 - 216
[48] Viral kinetics and duration of hepatitis C therapy
Kwo P.
Current Hepatitis Reports, 2010, 9 (3) : 140 - 146
[49] Hepatitis C viral kinetics in special populations
Dahari H.
Layden-Almer J.E.
Perelson A.S.
Layden T.J.
Current Hepatitis Reports, 2008, 7 (3) : 97 - 105
[50] Viral kinetics in the treatment of chronic hepatitis C
Layden-Almer, Jennifer E.
Cotler, Scott J.
Layden, Thomas J.
JOURNAL OF VIRAL HEPATITIS, 2006, 13 (08) : 499 - 504

← 1 2 3 4 5 →