Hepatitis C Viral Kinetics The Past, Present, and Future

被引：21
|
作者：
Chatterjee, Anushree [1 ,2 ]
Smith, Patrick F. [3 ]
Perelson, Alan S. [1 ]
机构：
[1] Los Alamos Natl Lab, Theoret Biol & Biophys, Los Alamos, NM 87545 USA
[2] Los Alamos Natl Lab, Ctr Nonlinear Studies, Los Alamos, NM 87545 USA
[3] Roche, Clin Pharmacol Pharma Res & Early Dev, Nutley, NJ USA
来源：
CLINICS IN LIVER DISEASE | 2013年 / 17卷 / 01期
关键词：
Mathematical modeling; Viral kinetics; Direct-acting antiviral agents; Protease inhibitors; Hepatitis C virus; DYNAMICS IN-VIVO; POLYMERASE INHIBITOR; ANTIVIRAL ACTIVITY; PROTEASE INHIBITORS; VIRUS-REPLICATION; TREATMENT-NAIVE; NONNUCLEOSIDE POLYMERASE; RESISTANCE MUTATIONS; ALPHA-INTERFERON; WILD-TYPE;
D O I：
10.1016/j.cld.2012.09.003
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Mathematical modeling of hepatitis C viral kinetics has been an important tool in understanding hepatitis C virus (HCV) infection dynamics and in estimating crucial in vivo parameters characterizing the effectiveness of HCV therapy. Because of the introduction of direct-acting antiviral agents, there is a need to extend previous models so as to understand, characterize, and compare various new HCV treatment regimens. Here we review recent modeling efforts in this direction.
引用
收藏
页码：13 / +
页数：15
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