Immune modulation in immune co-cultures of pancreatic ductal adenocarcinoma by small molecule CLK/WNT pathway inhibitor SM04690

被引：0

作者：

Dominguez, Adrian T. A. ^{[1
]}

Real, Adreanna G. ^{[1
]}

Levandowski, Cecilia B. ^{[1
]}

Lewis, Matthew S. ^{[1
]}

Hartman, Sarah ^{[1
]}

Yacob, Betelehem ^{[1
]}

Smoots, Stephen ^{[1
]}

Schreiber, Anna ^{[1
]}

Lanis, Jordi ^{[1
]}

Nepal, Pragya ^{[1
]}

Diamond, Jennifer ^{[1
]}

Lieu, Chris ^{[1
]}

Messersmith, Wells ^{[1
]}

Lang, Julie ^{[1
]}

Pitts, Todd ^{[1
]}

机构：

[1] Univ Colorado, Anschutz Med Campus, Aurora, CO USA

来源：

CANCER RESEARCH | 2022年 / 82卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

3509

引用

页数：2

共 44 条

[31] COMPARISON OF INTRA-ARTICULAR SHAM AND VEHICLE INJECTION FROM A PHASE 2B TRIAL OF SM04690, A SMALL-MOLECULE WNT INHIBITOR, FOR KNEE OSTEOARTHRITIS
Yazici, Y.
Tambiah, J.
Swearingen, C.
Kennedy, S.
Strand, V.
Cole, B.
Hochberg, M.
Bannuru, R.
McAlindon, T.
OSTEOARTHRITIS AND CARTILAGE, 2019, 27 : S241 - S242
[32] THE NOVEL, INTRA-ARTICULAR CLK/DYRK1A INHIBITOR LORECIVIVINT (SM04690), A WNT PATHWAY MODULATOR, IMPROVED RESPONDER OUTCOMES IN SUBJECTS WITH KNEE OSTEOARTHRITIS: A POST HOC ANALYSIS FROM A PHASE 2B TRIAL
Tambiah, J.
Kennedy, S.
Swearingen, C.
Yazici, Y.
OSTEOPOROSIS INTERNATIONAL, 2020, 31 (SUPPL 1) : S45 - S46
[33] The Novel, Intra-articular CLK/DYRK1A Inhibitor Lorecivivint (LOR; SM04690), Which Modulates the Wnt Pathway, Improved Responder Outcomes in Subjects with Knee Osteoarthritis: A Post Hoc Analysis from a Phase 2b Trial
Yazici, Yusuf
Kennedy, Sarah
Swearingen, Chris
Tambiah, Jeyanesh
ARTHRITIS & RHEUMATOLOGY, 2019, 71
[34] THE NOVEL, INTRA-ARTICULAR CLK/DYRK1A INHIBITOR LORECIVIVINT (LOR; SM04690), WHICH MODULATES THE WNT PATHWAY, IMPROVED RESPONDER OUTCOMES IN SUBJECTS WITH KNEE OSTEOARTHRITIS: A POST HOC ANALYSIS FROM A PHASE 2B TRIAL
Yazici, Y.
Kennedy, S.
Swearingen, C.
Tambiah, J.
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 809 - 810
[35] SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, downregulates the Wnt signaling pathway and demonstrates antitumor activity in pancreatic cancer cell lines and in vivo xenograft models
Bossard, Carine
Cruz, Nathalia
Eastman, Brian
Mak, Chi-Ching
Sunil, K. C.
Tam, Betty
Bucci, Gail
Stewart, Josh
Phalen, Timothy
Cha, Steven
CANCER RESEARCH, 2019, 79 (24)
[36] THE NOVEL, INTRA-ARTICULAR CLK/DYRK1A INHIBITOR LORECIVIVINT (LOR; SM04690), WHICH MODULATES THE WNT PATHWAY, IMPROVED RESPONDER OUTCOMES IN SUBJECTS WITH KNEE OSTEOARTHRITIS: A POST HOC ANALYSIS FROM A PHASE 2B TRIAL
Yazici, Yusuf
Kennedy, Sarah
Swearingen, Christopher I.
Tambiah, Jeyanesh
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2020, 26 : 120 - 121
[37] Transcriptome data-based status of PI3K/AKT/mTOR pathway indicates heterogeneity and immune modulation in patients with pancreatic ductal adenocarcinoma
Xie, Peng
Tan, Si-Yuan
Li, Hai-Feng
Tang, Hao-Dong
Zhou, Jia-hua
JOURNAL OF GENE MEDICINE, 2024, 26 (01):
[38] SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Mantle Cell Lymphoma Models
Chung, Heekyung
Creger, Emily
Sitts, Lauren
Chiu, Kevin
Mak, Chi-Ching
Sunil, K. C.
Tam, Betty
Bucci, Gail
Stewart, Josh
Phalen, Timothy
Cha, Steven
BLOOD, 2019, 134
[39] SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong inhibition of the Wnt signaling pathway and antitumor effects in diverse ovarian cancer models.
Chung, Heekyung
Sitts, Lauren
Creger, Emily
Liao, Erica
Eastman, Brian
Mak, Chi-Ching
Sunil, K. C.
Tam, Betty
Bucci, Gail
Stewart, Josh
Bossard, Carine
Phalen, Timothy
Cha, Steven
CLINICAL CANCER RESEARCH, 2020, 26 (13) : 41 - 42
[40] SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt pathway inhibition in castration-resistant prostate cancer (CRPC) models
Bossard, Carine
Cruz, Nathalia
Chiu, Kevin
Eastman, Brian
Mak, Chi Ching
Sunil, K. C.
Bucci, Gail
Stewart, Josh
Phalen, Timothy J.
Cha, Steven
CANCER RESEARCH, 2020, 80 (16)

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