Immune modulation in immune co-cultures of pancreatic ductal adenocarcinoma by small molecule CLK/WNT pathway inhibitor SM04690

被引：0

作者：

Dominguez, Adrian T. A. ^{[1
]}

Real, Adreanna G. ^{[1
]}

Levandowski, Cecilia B. ^{[1
]}

Lewis, Matthew S. ^{[1
]}

Hartman, Sarah ^{[1
]}

Yacob, Betelehem ^{[1
]}

Smoots, Stephen ^{[1
]}

Schreiber, Anna ^{[1
]}

Lanis, Jordi ^{[1
]}

Nepal, Pragya ^{[1
]}

Diamond, Jennifer ^{[1
]}

Lieu, Chris ^{[1
]}

Messersmith, Wells ^{[1
]}

Lang, Julie ^{[1
]}

Pitts, Todd ^{[1
]}

机构：

[1] Univ Colorado, Anschutz Med Campus, Aurora, CO USA

来源：

CANCER RESEARCH | 2022年 / 82卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

3509

引用

页数：2

共 44 条

[21] Lorecivivint (SM04690), an Intra-articular, Small-Molecule CLK/DYRK Inhibitor That Modulates the Wnt Pathway, Provided Cartilage-Protective Effects in an Animal Model of Post-traumatic OA
Seo, Timothy
Deshmukh, Vishal
Yazici, Yusuf
ARTHRITIS & RHEUMATOLOGY, 2021, 73 : 1961 - 1963
[22] MODULATION OF THE WNT PATHWAY THROUGH INHIBITION OF CLK2 AND DYRK1A BY SM04690: A NOVEL POTENTIAL DISEASE-MODIFYING TREATMENT FOR KNEE OSTEOARTHRITIS
Deshmukh, V.
O'Green, A.
Bossard, C.
Ibanez, M.
Seo, T.
Lamangan, L.
Ghias, A.
Lai, C.
Anderson, S.
Harris, R.
Cahiwat, J.
Chiu, K.
Pedraza, M.
Dellamary, L.
Kc, S.
Swearingen, C.
Marchand, P.
Barroga, C.
Tambiah, J.
Kennedy, S.
Melchior, B.
Tam, B.
Hood, J.
Yazici, Y.
OSTEOPOROSIS INTERNATIONAL, 2019, 30 : S311 - S311
[23] INTEGRATED SAFETY SUMMARY OF THE NOVEL, INTRA-ARTICULAR AGENT LORECIVIVINT (SM04690), A CLK/DYRK1A INHIBITOR THAT MODULATES THE WNT PATHWAY, IN SUBJECTS WITH KNEE OSTEOARTHRITIS
Simsek, I.
Swearingen, C.
Kennedy, S.
Tambiah, J.
Damatarca, C.
Yazici, Y.
Lane, N.
Hochberg, M.
ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 117 - 117
[24] LORECIVIVINT (SM04690), AN INTRA-ARTICULAR, SMALL-MOLECULE CLK2/DYRK1A INHIBITOR THAT MODULATES THE WNT PATHWAY, PROVIDED CARTILAGE-PROTECTIVE EFFECTS IN AN ANIMAL MODEL OF POST-TRAUMATIC OA
Seo, T.
Deshmukh, V.
Yazici, Y.
ANNALS OF THE RHEUMATIC DISEASES, 2021, 80 : 60 - 60
[25] Safety Profile to Date of the Novel, Intra-articular Agent Lorecivivint (LOR; SM04690), a CLK/DYRK1A Inhibitor That Modulates the Wnt Pathway, in Subjects with Knee Osteoarthritis
Simsek, Ismail
Swearingen, Chris
Kennedy, Sarah
Tambiah, Jeyanesh
Yazici, Yusuf
Lane, Nancy
Hochberg, Marc C.
ARTHRITIS & RHEUMATOLOGY, 2019, 71
[26] INTEGRATED SAFETY SUMMARY OF THE NOVEL, INTRA-ARTICULAR AGENT LORECIVIVINT (SM04690), A CLK/DYRK1A INHIBITOR THAT MODULATES THE WNT PATHWAY, IN SUBJECTS WITH KNEE OSTEOARTHRITIS
Kennedy, Sarah
Simsek, Ismail
Swearingen, Christopher J.
Tambiah, Jeyanesh
Damatarca, Cristina
Yazici, Yusuf
Lane, Nancy E.
Hochberg, Marc C.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2020, 26 : 121 - 121
[27] COMPARISON OF INTRA-ARTICULAR SHAM AND VEHICLE INJECTIONS FROM A PHASE 2B TRIAL OF SM04690, A SMALL-MOLECULE WNT PATHWAY INHIBITOR FOR KNEE OSTEOARTHRITIS
Yazici, Yusuf
Tambiah, Jeyanesh
Swearingen, Christopher
Kennedy, Sarah
Strand, Vibeke
Cole, Brian
Hochberg, Marc
Bannuru, Raveendhara
Mcalindon, Timothy
ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 494 - 494
[28] INTEGRATED SAFETY SUMMARY OF THE NOVEL, INTRA-ARTICULAR AGENT LORECIVIVINT (LOR; SM04690), A CLK/DYRK1A INHIBITOR THAT MODULATES THE WNT PATHWAY, IN SUBJECTS WITH KNEE OSTEOARTHRITIS
Simsek, I.
Swearingen, C.
Kennedy, S.
Tambiah, J.
Damatarca, C.
Yazici, Y.
Lane, N.
Hochberg, M.
OSTEOPOROSIS INTERNATIONAL, 2020, 31 (SUPPL 1) : S606 - S607
[29] Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma
Holokai, Loryn
Chakrabarti, Jayati
Lundy, Joanne
Croagh, Daniel
Adhikary, Pritha
Richards, Scott S.
Woodson, Chantal
Steele, Nina
Kuester, Robert
Scott, Aaron
Khreiss, Mohammad
Frankel, Timothy
Merchant, Juanita
Jenkins, Brendan J.
Wang, Jiang
Shroff, Rachna T.
Ahmad, Syed A.
Zavros, Yana
CANCERS, 2020, 12 (12) : 1 - 25
[30] Radiographic Outcomes Were Associated with Pain and Function Responses: Post-Hoc Analysis of Results from a Phase 2 Study of a Small Molecule Wnt Pathway Inhibitor, SM04690, for Knee Osteoarthritis Treatment
Yazici, Yusuf
McAlindon, Timothy E.
Gibofsky, Allan
Lane, Nancy E.
Skrepnik, Nebojsa
Armas, Eddie
Swearingen, Christopher J.
DiFrancesco, Anita
Tambiah, Jeymi
Hochberg, Marc
ARTHRITIS & RHEUMATOLOGY, 2017, 69

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