First Detection of Colistin-Resistant Klebsiella pneumoniae in Association with NDM-5 Carbapenemase Isolated from Clinical Lebanese Patients

被引：24
|
作者：
Dagher, Tania Nawfal [1 ,2 ,3 ]
Azar, Eid [3 ]
Al-Bayssari, Charbel [4 ]
Chamieh, Amanda S. [3 ]
Rolain, Jean-Marc [1 ,2 ]
机构：
[1] IRD, APHM, MEPHI, IHU Mediterranee Infect, Marseille, France
[2] Aix Marseille Univ, Fac Med & Pharm, Marseille 05, France
[3] Univ Balamand, St George Hosp Univ, Fac Med & Med Sci, Med Ctr, Beirut, Lebanon
[4] Lebanese Univ, Fac Sci 3, Tripoli, Libya
来源：
MICROBIAL DRUG RESISTANCE | 2019年 / 25卷 / 06期
关键词：
NDM-5; Klebsiella pneumoniae; carbapenem resistance; colistin resistance; METALLO-BETA-LACTAMASE; ACINETOBACTER-BAUMANNII; ESCHERICHIA-COLI; GENES; PLASMIDS;
D O I：
10.1089/mdr.2018.0383
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This study aims to describe the molecular mechanisms of carbapenem and colistin resistance in Klebsiella pneumoniae strains isolated from hospitalized patients in Lebanon. We report in this study the first description of NDM-5 producing carbapenem-resistant K. pneumoniae ST383, as well as the presence of two out of five isolates resistant to colistin due to mutations in the amino acid sequences of proteins (PmrB, PhoQ, and MgrB). Therefore, screening of such isolates may be effective in limiting the spread of these resistant microorganisms in hospitalized patients and within the community.
引用
收藏
页码：925 / 930
页数：6
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