First Detection of Colistin-Resistant Klebsiella pneumoniae in Association with NDM-5 Carbapenemase Isolated from Clinical Lebanese Patients

被引：24
|
作者：
Dagher, Tania Nawfal [1 ,2 ,3 ]
Azar, Eid [3 ]
Al-Bayssari, Charbel [4 ]
Chamieh, Amanda S. [3 ]
Rolain, Jean-Marc [1 ,2 ]
机构：
[1] IRD, APHM, MEPHI, IHU Mediterranee Infect, Marseille, France
[2] Aix Marseille Univ, Fac Med & Pharm, Marseille 05, France
[3] Univ Balamand, St George Hosp Univ, Fac Med & Med Sci, Med Ctr, Beirut, Lebanon
[4] Lebanese Univ, Fac Sci 3, Tripoli, Libya
来源：
MICROBIAL DRUG RESISTANCE | 2019年 / 25卷 / 06期
关键词：
NDM-5; Klebsiella pneumoniae; carbapenem resistance; colistin resistance; METALLO-BETA-LACTAMASE; ACINETOBACTER-BAUMANNII; ESCHERICHIA-COLI; GENES; PLASMIDS;
D O I：
10.1089/mdr.2018.0383
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This study aims to describe the molecular mechanisms of carbapenem and colistin resistance in Klebsiella pneumoniae strains isolated from hospitalized patients in Lebanon. We report in this study the first description of NDM-5 producing carbapenem-resistant K. pneumoniae ST383, as well as the presence of two out of five isolates resistant to colistin due to mutations in the amino acid sequences of proteins (PmrB, PhoQ, and MgrB). Therefore, screening of such isolates may be effective in limiting the spread of these resistant microorganisms in hospitalized patients and within the community.
引用
收藏
页码：925 / 930
页数：6
相关论文
共 50 条
  • [21] An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread
    Weterings, V.
    Zhou, K.
    Rossen, J. W.
    van Stenis, D.
    Thewessen, E.
    Kluytmans, J.
    Veenemans, J.
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2015, 34 (08) : 1647 - 1655
  • [22] Epidemiology and molecular characterisation of colistin-resistant Klebsiella pneumoniae isolates from immunocompromised patients in Tunisia
    Ben Tanfous, Farah
    Raddaoui, Anis
    Chebbi, Yosra
    Achour, Wafa
    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2018, 52 (06) : 861 - 865
  • [23] Global distribution, genotypes and prevalent sequence types of colistin-resistant Klebsiella pneumoniae isolated from clinical samples; A systematic review
    Sameni, Fatemeh
    Ghazi, Mona
    Dadashi, Masoud
    Bostanshirin, Nazila
    Al-Dahmoshi, Hussein O. M.
    Khosravi-Dehaghi, Nafiseh
    Nasiri, Mohammad Javad
    Goudarzi, Mehdi
    Hajikhani, Bahareh
    GENE REPORTS, 2022, 28
  • [24] Genomic Insights into Colistin-Resistant Klebsiella pneumoniae from a Tunisian Teaching Hospital
    Jaidane, Nadia
    Bonnin, Remy A.
    Mansour, Wejdene
    Girlich, Delphine
    Creton, Elodie
    Cotellon, Garance
    Chaouch, Cherifa
    Boujaafar, Noureddine
    Bouallegue, Olfa
    Naas, Thierry
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018, 62 (02)
  • [25] Genome analyses of colistin-resistant high-risk bla NDM-5 producing Klebsiella pneumoniae ST147 and Pseudomonas aeruginosa ST235 and ST357 in clinical settings
    Talat, Absar
    Khan, Fatima
    Khan, Asad U.
    BMC MICROBIOLOGY, 2024, 24 (01):
  • [26] Detection of morphological variants of colistin-resistant Klebsiella pneumoniae associated with sepsis in Kerala, India
    Paul, Merin
    Thomas, Sabu
    ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2025, 72 (01) : 39 - 42
  • [27] Open Conversion after Aortic Endograft Infection Caused by Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae
    Montelione, Nunzio
    Menna, Danilo
    Sirignano, Pasqualino
    Capoccia, Laura
    Mansour, Wassim
    Speziale, Francesco
    TEXAS HEART INSTITUTE JOURNAL, 2016, 43 (05): : 453 - 457
  • [28] Emergence of mcr-1 gene and carbapenemase-encoding genes among colistin-resistant Klebsiella pneumoniae clinical isolates in Jordan
    Gharaibeh, Mohammad H.
    Alyafawi, Dania A.
    Elnasser, Ziad A.
    Lafi, Shawkat Q.
    Obeidat, Haneen M.
    JOURNAL OF INFECTION AND PUBLIC HEALTH, 2022, 15 (08) : 922 - 929
  • [29] Genomic Insights into Two Colistin-Resistant Klebsiella pneumoniae Strains Isolated from the Stool of Preterm Neonate During the First Week of Life
    Yap, Polly Soo Xi
    Kamar, Azanna Ahmad
    Chong, Chun Wie
    Ngoi, Soo Tein
    Teh, Cindy Shuan Ju
    MICROBIAL DRUG RESISTANCE, 2020, 26 (03) : 190 - 203
  • [30] Colistin-resistant isolates of Klebsiella pneumoniae emerging in intensive care unit patients:: first report of a multiclonal cluster
    Antoniadou, Anastasia
    Kontopidou, Flora
    Poulakou, Garifalia
    Koratzanis, Evangelos
    Galani, Irene
    Papadomichelakis, Evangelos
    Kopterides, Petros
    Souli, Maria
    Armaganidis, Apostolos
    Giamarellou, Helen
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (04) : 786 - 790
12345