Advances in proteomics data analysis and display using an accurate mass and time tag approach

被引：260
|
作者：
Zimmer, JSD
Monroe, ME
Qian, WJ
Smith, RD
机构：
[1] Pacific NW Natl Lab, Div Biol Sci, Richland, WA 99352 USA
[2] Pacific NW Natl Lab, Environm Mol Sci Lab, Richland, WA 99352 USA
来源：
MASS SPECTROMETRY REVIEWS | 2006年 / 25卷 / 03期
关键词：
FTICR-MS; proteomics; AMT tag; SPICAT; QCET; PhIST;
D O I：
10.1002/mas.20071
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Proteomics has recently demonstrated utility for increasing the understanding of cellular processes on the molecular level as a component of systems biology approaches and for identifying potential biomarkers of various disease states. The large amount of data generated by utilizing high efficiency (e.g., chromatographic) separations coupled with high mass accuracy mass spectrometry for high-throughput proteomics analyses presents challenges related to data processing, analysis, and display. This review focuses on recent advances in nanoLC-FTICR-MS-based proteomics approaches and the accompanying data processing tools that have been developed to display and interpret the large volumes of data being produced. (c) 2006 Wiley Periodicals, Inc.
引用
收藏
页码：450 / 482
页数：33
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