Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release

被引：36

作者：

Ozkahraman, Bengi ^{[1
]}

Tamahkar, Emel ^{[2
,3
]}

Idil, Neslihan ^{[4
]}

Kilic Suloglu, Aysun ^{[4
]}

Percin, Isik ^{[4
]}

机构：

[1] Hitit Univ, Dept Polymer Engn, Corum, Turkey

[2] Hitit Univ, Dept Chem Engn, Corum, Turkey

[3] Balikesir Univ, Dept Food Engn, Balikesir, Turkey

[4] Hacettepe Univ, Dept Biol, Ankara, Turkey

来源：

DRUG DEVELOPMENT RESEARCH | 2021年 / 82卷 / 02期

关键词：

antibiotic release; chitosan-gelatin hydrogels; hyaluronic acid nanoparticles embedding; DRUG-RELEASE; DELIVERY; FILMS; SCAFFOLDS;

D O I：

10.1002/ddr.21747

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified.

引用

页码：241 / 250

页数：10

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