Evaluation of hyaluronic acid nanoparticle embedded chitosan-gelatin hydrogels for antibiotic release

被引：36
|
作者：
Ozkahraman, Bengi [1 ]
Tamahkar, Emel [2 ,3 ]
Idil, Neslihan [4 ]
Kilic Suloglu, Aysun [4 ]
Percin, Isik [4 ]
机构：
[1] Hitit Univ, Dept Polymer Engn, Corum, Turkey
[2] Hitit Univ, Dept Chem Engn, Corum, Turkey
[3] Balikesir Univ, Dept Food Engn, Balikesir, Turkey
[4] Hacettepe Univ, Dept Biol, Ankara, Turkey
来源：
DRUG DEVELOPMENT RESEARCH | 2021年 / 82卷 / 02期
关键词：
antibiotic release; chitosan-gelatin hydrogels; hyaluronic acid nanoparticles embedding; DRUG-RELEASE; DELIVERY; FILMS; SCAFFOLDS;
D O I：
10.1002/ddr.21747
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The development of chitosan-gelatin (CS-G) hydrogels embedded with ampicillin-loaded hyaluronic acid nanoparticles (HA-NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA-NPs into biocompatible CS-G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS-G/HA-NPs hydrogels after 5 days. Antibacterial performance of CS-G/HA-NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS-G/HA-NPs hydrogels compared with CS-G group after 24 hr incubation. Consequently, the potential ability of CS-G/HA-NPs hydrogels as a controlled drug delivery system has been verified.
引用
收藏
页码：241 / 250
页数：10
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