An MRI study of amygdala in schizophrenia and psychotic bipolar disorder

被引：20

作者：

Mahon, Pamela Belmonte ^{[1
]}

Eldridge, Haley ^{[1
]}

Crocker, Britni ^{[2
]}

Notes, Lisa ^{[1
]}

Gindes, Holly ^{[1
]}

Postell, Elizabeth ^{[2
]}

King, Stacey ^{[1
]}

Potash, James B. ^{[1
]}

Ratnanather, J. Tilak ^{[2
,3
]}

Barta, Patrick E. ^{[2
]}

机构：

[1] Johns Hopkins Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA

[2] Johns Hopkins Univ, Ctr Imaging Sci, Baltimore, MD USA

[3] Johns Hopkins Univ, Inst Computat Med, Baltimore, MD USA

来源：

SCHIZOPHRENIA RESEARCH | 2012年 / 138卷 / 2-3期

关键词：

Amygdala; MRI; Psychotic bipolar disorder; Schizophrenia; ADULT HUMAN BRAIN; HIPPOCAMPAL-FORMATION; ALZHEIMERS-DISEASE; VOLUMES; METAANALYSIS; SEX; CLASSIFICATION; INTERVIEW; FEATURES; LITHIUM;

D O I：

10.1016/j.schres.2012.04.005

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had smaller amygdala compared with patients with psychotic bipolar disorder (p=0.014). These results suggest that change in volume of amygdala may represent a morphologic feature distinguishing psychotic bipolar disorder from schizophrenia. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：188 / 191

页数：4

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