A case study of a child with chronic hemolytic anemia due to a Donath-Landsteiner positive, IgM anti-I autoantibody

被引：9
|
作者：
Karafin, Matthew S. [2 ]
Shirey, R. Sue [2 ]
Ness, Paul M. [2 ]
King, Karen E. [2 ]
Keefer, Jeffrey [1 ]
机构：
[1] Johns Hopkins Univ Hosp, Johns Hopkins Med Inst, Dept Pediat, Div Pediat Hematol, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ Hosp, Dept Pathol, Div Transfus Med, Baltimore, MD 21287 USA
来源：
PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 05期
关键词：
anemias; blood bank; IVIG; hemolytic anemia; immunotherapy; PAROXYSMAL COLD HEMOGLOBINURIA; BIPHASIC HEMOLYSIN; AUTOIMMUNE HEMOLYSIS; ANTIBODIES;
D O I：
10.1002/pbc.24185
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In children, paroxysmal cold hemoglobinuria (PCH) is generally considered an acute self-limited autoimmune hemolytic anemia caused by an IgG biphasic auto-anti-P antibody identified by the DonathLandsteiner (D-L) test. We report a case of a 5-year-old female with a chronic hemolytic anemia. The etiology of the hemolysis appears to be an unusual D-L positive, IgM antibody with specificity for the I antigen. The clinical course is described and a discussion of PCH and the D-L antibody is presented. We also discuss intravenous immunoglobulin infusions as a therapy for children with this form of severe chronic autoimmune hemolytic anemia. Pediatr Blood Cancer 2012; 59: 953955. (C) 2012 Wiley Periodicals, Inc.
引用
收藏
页码：953 / 955
页数：3
相关论文
共 22 条
  • [1] Recurrent Donath-Landsteiner hemolytic anemia: a pediatric case report
    Prince, Sara D.
    Winestone, Lena E.
    Nance, Sandra J.
    Friedman, David F.
    TRANSFUSION, 2017, 57 (06) : 1401 - 1406
  • [2] A rare cause of Acquired Hemolytic Anemia in a child; Donath-Landsteiner antibody
    Abdelmonem, M.
    Shan, H.
    Cai, W.
    Roque, A.
    Chang, S.
    Cabungan, M.
    Papakonstantino, K.
    Virk, M. S.
    Yunce, M.
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2023, 160 : S109 - S110
  • [3] A rare cause of Acquired Hemolytic Anemia in a child; Donath-Landsteiner antibody
    Abdelmonem, M.
    Shan, H.
    Cai, W.
    Roque, A.
    Chang, S.
    Cabungan, M.
    Papakonstantino, K.
    Virk, M. S.
    Yunce, M.
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2023, 160 : S109 - S110
  • [4] DONATH-LANDSTEINER HEMOLYTIC-ANEMIA DUE TO AN ANTI-PR-LIKE BIPHASIC HEMOLYSIN
    JUDD, WJ
    WILKINSON, SL
    ISSITT, PD
    JOHNSON, TL
    KEREN, DF
    STEINER, EA
    TRANSFUSION, 1986, 26 (05) : 423 - 425
  • [5] INFECTIOUS MONONUCLEOSIS COMPLICATED BY ACUTE HEMOLYTIC-ANEMIA WITH A POSITIVE DONATH-LANDSTEINER REACTION
    WISHART, MM
    DAVEY, MG
    JOURNAL OF CLINICAL PATHOLOGY, 1973, 26 (05) : 332 - 334
  • [6] DONATH-LANDSTEINER AUTOIMMUNE HEMOLYTIC-ANEMIA IN CHILDREN - A STUDY OF 22 CASES
    GOTTSCHE, B
    SALAMA, A
    MUELLERECKHARDT, C
    VOX SANGUINIS, 1990, 58 (04) : 281 - 286
  • [7] A rare case report of autoimmune haemolytic anemia in a female child due to a Donath-Landsteiner antibody
    Radonjic, Z.
    Andric, B.
    Serbic, O.
    Micic, D.
    Kuzmanovic, M.
    Jovanovic-Srzentic, S.
    Dinic, R.
    TRANSFUSION CLINIQUE ET BIOLOGIQUE, 2020, 27 (02) : 83 - 86
  • [8] Donath-Landsteiner antibody-associated hemolytic anemia after Haemophilus influenzae infection in a child
    Ziman, A
    Hsi, R
    Goldfinger, D
    TRANSFUSION, 2004, 44 (08) : 1127 - 1128
  • [9] Successful Treatment of Warm Autoimmune Hemolytic Anemia with a Positive Donath-Landsteiner Test Using Rituximab
    Hiranuma, Naoko
    Koba, Yusuke
    Kawata, Takahito
    Tamekane, Akira
    Watanabe, Mitsumasa
    INTERNAL MEDICINE, 2024, 63 (15) : 2173 - 2176
  • [10] INFECTIOUS-MONONUCLEOSIS COMPLICATED BY HEMOLYTIC-ANEMIA DUE TO THE DONATH-LANDSTEINER ANTIBODY AND BY SEVERE NEUTROPENIA
    UZOKWE, CO
    GWYNN, AM
    GORST, DW
    ADAMSON, AR
    CLINICAL AND LABORATORY HAEMATOLOGY, 1993, 15 (02): : 137 - 140
123