A case study of a child with chronic hemolytic anemia due to a Donath-Landsteiner positive, IgM anti-I autoantibody

被引：9

作者：

Karafin, Matthew S. ^{[2
]}

Shirey, R. Sue ^{[2
]}

Ness, Paul M. ^{[2
]}

King, Karen E. ^{[2
]}

Keefer, Jeffrey ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Johns Hopkins Med Inst, Dept Pediat, Div Pediat Hematol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ Hosp, Dept Pathol, Div Transfus Med, Baltimore, MD 21287 USA

来源：

PEDIATRIC BLOOD & CANCER | 2012年 / 59卷 / 05期

关键词：

anemias; blood bank; IVIG; hemolytic anemia; immunotherapy; PAROXYSMAL COLD HEMOGLOBINURIA; BIPHASIC HEMOLYSIN; AUTOIMMUNE HEMOLYSIS; ANTIBODIES;

D O I：

10.1002/pbc.24185

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In children, paroxysmal cold hemoglobinuria (PCH) is generally considered an acute self-limited autoimmune hemolytic anemia caused by an IgG biphasic auto-anti-P antibody identified by the DonathLandsteiner (D-L) test. We report a case of a 5-year-old female with a chronic hemolytic anemia. The etiology of the hemolysis appears to be an unusual D-L positive, IgM antibody with specificity for the I antigen. The clinical course is described and a discussion of PCH and the D-L antibody is presented. We also discuss intravenous immunoglobulin infusions as a therapy for children with this form of severe chronic autoimmune hemolytic anemia. Pediatr Blood Cancer 2012; 59: 953955. (C) 2012 Wiley Periodicals, Inc.

引用

页码：953 / 955

页数：3

共 22 条

[21] Successful anti-CD20 monoclonal antibody treatment of severe autoimmune hemolytic anemia due to warm reactive IgM autoantibody in a child with common variable immunodeficiency
Wakim, M
Shah, A
Arndt, PA
Garratty, G
Weinberg, K
Hofstra, T
Church, J
AMERICAN JOURNAL OF HEMATOLOGY, 2004, 76 (02) : 152 - 155
[22] Successful anti-CD20 monoclonal antibody treatment of severe autoimmune hemolytic anemia due to warm reactive IgM antibody in a child with common variable immunodeficiency
Wakim, M
Weinberg, K
Shah, A
Arndt, P
Garratty, G
Hofstra, T
Church, JA
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (01) : S189 - S189

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