QUANTITATIVE SYSTEMS PHARMACOLOGY MODELING OF T CELL ACTIVATION AND CD28/CTLA4 CO-SIGNALING INTERACTION.

被引:0
|
作者
Holland, D. [1 ]
Ji, Y. [2 ]
Gomes, B. [3 ]
机构
[1] Johns Hopkins Sch Med, Baltimore, MD USA
[2] Novartis, E Hanover, NJ USA
[3] Novartis, Cambridge, MA USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
PI-093
引用
收藏
页码:S39 / S39
页数:1
相关论文
共 50 条
  • [41] DISTINCT MECHANISMS OF T-CELL SIGNAL-TRANSDUCTION BY CD28 AND CTLA4, AND BY LIGANDS B7-1 AND B7-2
    UEDA, Y
    FREEMAN, G
    LEVINE, B
    WARD, SG
    HUANG, ML
    ABE, R
    NADLER, LM
    JUNE, CH
    CLINICAL RESEARCH, 1994, 42 (02): : A309 - A309
  • [42] Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4
    Walker, LSK
    Wiggett, HE
    Gaspal, FMC
    Raykundalia, CR
    Goodall, MD
    Toellner, KM
    Lane, PJL
    JOURNAL OF IMMUNOLOGY, 2003, 170 (01): : 91 - 98
  • [43] LSECtin (CLEC4G) inhibits T-cell activation and proliferation in the presence of TCR and CD28 signaling
    Wang, Jinghua
    Manick, Brian
    Renelt, Mark
    Gerassenkov, Tatsiana
    Bi, Ming
    Kalabokis, Vassilios
    Person, Anthony
    Wu, Guoping
    JOURNAL OF IMMUNOLOGY, 2021, 206
  • [44] Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo
    Krummel, MF
    Sullivan, TJ
    Allison, JP
    INTERNATIONAL IMMUNOLOGY, 1996, 8 (04) : 519 - 523
  • [45] Polymorphism of costimulatory molecules (CTLA4, ICOS, PD.1 and CD28) and allogeneic hematopoietic stem cell transplantation in Iranian patients
    Iravani-Saadi, Mahdiyar
    Karimi, Mohammad Hossein
    Yaghobi, Ramin
    Geramizadeh, Bita
    Ramzi, Mani
    Niknam, Ahmad
    Pourfathollah, Arefeh
    IMMUNOLOGICAL INVESTIGATIONS, 2014, 43 (04) : 391 - 404
  • [46] Monocyte: T-cell interaction regulates human T-cell activation through a CD28/CD46 crosstalk
    Charron, Lauren
    Doctrinal, Axelle
    Choileain, Siobhan Ni
    Astier, Anne L.
    IMMUNOLOGY AND CELL BIOLOGY, 2015, 93 (09): : 796 - 803
  • [47] CTLA4-Ig-Based Bifunctional Costimulation Inhibitor Blocks CD28 and ICOS Signaling to Prevent T Cell Priming and Effector Function
    Goenka, Radhika
    Xu, Zhenghai
    Samayoa, Josue
    Banach, David
    Beam, Christine
    Bose, Sahana
    Dooner, Gerri
    Forsyth, Charles M.
    Lu, Xiaoqing
    Medina, Limary
    Sadhukhan, Ramkrishna
    Sielaff, Bernhard
    Sousa, Silvino
    Tao, Qingfeng
    Touw, Debra
    Wu, Fei
    Kingsbury, Gillian A.
    Akamatsu, Yoshiko
    JOURNAL OF IMMUNOLOGY, 2021, 206 (05): : 1102 - 1113
  • [48] The role of CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) in regulatory T-cell biology
    Sansom, David M.
    Walker, Lucy S. K.
    IMMUNOLOGICAL REVIEWS, 2006, 212 : 131 - 148
  • [49] CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement
    Wang, Chun Jing
    Heuts, Frank
    Ovcinnikovs, Vitalijs
    Wardzinski, Lukasz
    Bowers, Chantelle
    Schmidt, Emily M.
    Kogimtzis, Alexandros
    Kenefeck, Rupert
    Sansom, David M.
    Walker, Lucy S. K.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (02) : 524 - 529
  • [50] Inhibition of T cell proliferation by cholera toxin involves the modulation of costimulatory molecules CTLA-4 and CD28
    Vendetti, Silvia
    Riccomi, Antonella
    Sacchi, Alessandra
    Sciaraffia, Ester
    Gatta, Lucia
    Pioli, Claudio
    De Magistris, Maria Teresa
    IMMUNOLOGY LETTERS, 2008, 115 (01) : 59 - 69