How Tumor Virology Evolved into Cancer Biology and Transformed Oncology

被引：10
|
作者：
Varmus, Harold [1 ]
机构：
[1] Weill Cornell Med, Meyer Canc Ctr, New York, NY 10065 USA
来源：
ANNUAL REVIEW OF CANCER BIOLOGY, VOL 1 | 2017年 / 1卷
关键词：
retroviruses; oncogenes; genomics; targeted therapy; oncology; DEPENDENT DNA-POLYMERASE; AVIAN-SARCOMA VIRUSES; GENE; INHIBITOR; SEQUENCES; ONCOGENE; IDENTIFICATION; SUPPRESSION; ACTIVATION; HALLMARKS;
D O I：
10.1146/annurev-cancerbio-050216-034315
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The field of cancer biology has recently come of age, as witnessed by the initiation of this Annual Reviews journal this year. In this article, I argue that the major sources of cancer biology reside neither in cell biology nor in traditional cancer research, but instead in the domain once called "tumor virology." Speaking from the perspective of someone who "rode the wave" that uncovered cancer genes and their effects on cell behavior, I have tried to trace the influences, discoveries, and changing attitudes and practices that produced the vibrant scientific landscape that we now enjoy.
引用
收藏
页码：1 / 18
页数：18
相关论文
共 50 条
  • [31] TUMOR MARKERS AND BIOLOGY IN GASTROESOPHAGEAL CANCER
    Ebert, M.
    ANNALS OF ONCOLOGY, 2012, 23 : 37 - 37
  • [32] Computational Biology Helps Understand How Polyploid Giant Cancer Cells Drive Tumor Success
    Casotti, Matheus Correia
    Meira, Debora Dummer
    Zetum, Alexia Stefani Siqueira
    de Araujo, Bruno Cancian
    da Silva, Danielle Ribeiro Campos
    dos Santos, Eldamaria de Vargas Wolfgramm
    Garcia, Fernanda Mariano
    de Paula, Flavia
    Santana, Gabriel Mendonca
    Louro, Luana Santos
    Alves, Lyvia Neves Rebello
    Braga, Raquel Furlani Rocon
    Trabach, Raquel Silva dos Reis
    Bernardes, Sara Santos
    Louro, Thomas Erik Santos
    Chiela, Eduardo Cremonese Filippi
    Lenz, Guido
    de Carvalho, Elizeu Fagundes
    Louro, Iuri Drumond
    GENES, 2023, 14 (04)
  • [33] Circulating tumor cells: quintessential precision oncology presenting challenges for biology
    Rebecca J. Morris
    npj Precision Oncology, 1
  • [34] Circulating tumor cells: quintessential precision oncology presenting challenges for biology
    Morris, Rebecca J.
    NPJ PRECISION ONCOLOGY, 2017, 1
  • [35] Relevance of hypoxia in radiation oncology: pathophysiology, tumor biology and implications for treatment
    Busk, M.
    Horsman, M. R.
    QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 57 (03): : 219 - 234
  • [36] Radiogenomics In Neuro-Oncology: A Noninvasive Way of Understanding Tumor Biology
    Doddamani, Ramesh
    Chandra, Poodipedi Sarat
    NEUROLOGY INDIA, 2024, 72 (04) : 698 - 699
  • [37] Classic paper: How monolayer cell culture transformed diagnostic virology: a review of a classic paper and the developments that stemmed from it
    Enders, John F.
    Weller, Thomas H.
    Robbins, Frederick C.
    Mortimer, P.
    REVIEWS IN MEDICAL VIROLOGY, 2009, 19 (04) : 241 - 249
  • [38] From Self-Organization to Tumor-Immune Therapy: How Things Started and How They Evolved
    Barz, Matthias
    Nuhn, Lutz
    Hoerpel, Gerhard
    Zentel, Rudolf
    MACROMOLECULAR RAPID COMMUNICATIONS, 2022, 43 (12)
  • [39] Vascular invasion in pancreatic cancer: Tumor biology or tumor topography?
    Rehders, Alexander
    Stoecklein, Nikolas H.
    Gueray, Ayse
    Riediger, Rouwen
    Alexander, Andrea
    Knoefel, Wolfram Trudo
    SURGERY, 2012, 152 (03) : S143 - S151
  • [40] Cancer Genome Explosion and Systems Biology: Impact on Surgical Oncology?
    Dimitrios H. Roukos
    Annals of Surgical Oncology, 2011, 18 : 12 - 15
12345