Neural progenitor cells regulate microglia functions and activity

被引：175

作者：

Mosher, Kira I. ^{[1
,2
]}

Andres, Robert H. ^{[3
]}

Fukuhara, Takeshi ^{[1
]}

Bieri, Gregor ^{[1
,2
]}

Hasegawa-Moriyama, Maiko ^{[1
]}

He, Yingbo ^{[1
]}

Guzman, Raphael ^{[3
]}

Wyss-Coray, Tony ^{[1
,4
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Neurosci IDP Program, Stanford, CA 94305 USA

[3] Stanford Univ, Med Ctr, Dept Neurosurg, Stanford, CA 94305 USA

[4] Vet Adm Palo Alto Hlth Care Syst, Ctr Tissue Regenerat Repair & Restorat, Palo Alto, CA USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 11期

基金：

瑞士国家科学基金会; 美国国家卫生研究院; 美国国家科学基金会;

关键词：

ADULT HIPPOCAMPAL NEUROGENESIS; ENDOTHELIAL GROWTH-FACTOR; RECOVERY; BRAIN;

D O I：

10.1038/nn.3233

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.

引用

页码：1485 / 1487

页数：3

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