Peculiarities of Intracellular Signal Transduction in the Regulation of Functions of Mesenchymal, Neural, and Hematopoietic Progenitor Cells

被引：13

作者：

Zyuz'kov, G. N. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

Udut, E. V. ^{[1
,2
]}

Miroshnichenko, L. A. ^{[1
]}

Polyakova, T. Yu. ^{[1
]}

Stavrova, L. A. ^{[1
]}

Chaikovskii, A. V. ^{[1
]}

Simanina, E. V. ^{[1
]}

Minakova, M. Yu. ^{[1
]}

Udut, V. V. ^{[1
,2
]}

机构：

[1] Tomsk Natl Res Med Ctr, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia

[2] Tomsk State Univ, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 167卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

signal transduction; regenerative medicine; stem cells; medical remedies; targeted therapy; PROLIFERATION; INHIBITION; JNK; P53;

D O I：

10.1007/s10517-019-04491-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The role of NF-kappa B, cAMP/PKA, JAKs/STAT3, ERK1/2, p38, JNK, and p53 signaling pathways in the realization of growth potential of mesenchymal, neural, erythroid, and granulomonocytic progenitor cells were examined in vitro. Using selective blockers of signaling molecules, we revealed some principal distinctions of their involvement in determination of proliferation-differentiation status of the progenitor cells of different functional classes. The most salient peculiarities were observed in the roles of cAMP/PKA, JNK, and JAKs/STAT3 signaling pathways in the control of functions of various types of the regeneration-competent elements. The specific features of intracellular signaling revealed in histogenetically and functionally different progenitor cells attest to visibility of differentiated pharmacological stimulation of regeneration in individual tissues and prospectiveness in the development of targeted remedies for regenerative medicine based on modifiers of activity of the intracellular signaling molecules.

引用

页码：201 / 206

页数：6

共 50 条

[1] Peculiarities of Intracellular Signal Transduction in the Regulation of Functions of Mesenchymal, Neural, and Hematopoietic Progenitor Cells
G. N. Zyuz’kov
V. V. Zhdanov
E. V. Udut
L. A. Miroshnichenko
T. Yu. Polyakova
L. A. Stavrova
A. V. Chaikovskii
E. V. Simanina
M. Yu. Minakova
V. V. Udut
Bulletin of Experimental Biology and Medicine, 2019, 167 : 201 - 206
[2] Specific Features of Intracellular Signal Transduction in the Regulation of Functions of Neural Stem Cells and Committed Neuronal Progenitors
G. N. Zyuz’kov
L. A. Miroshnichenko
T. Yu. Polyakova
V. V. Zhdanov
E. V. Simanina
L. A. Stavrova
M. G. Danilets
Bulletin of Experimental Biology and Medicine, 2021, 170 : 522 - 527
[3] Specific Features of Intracellular Signal Transduction in the Regulation of Functions of Neural Stem Cells and Committed Neuronal Progenitors
Zyuz'kov, G. N.
Miroshnichenko, L. A.
Polyakova, T. Yu
Zhdanov, V. V.
Simanina, E., V
Stavrova, L. A.
Danilets, M. G.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2021, 170 (04) : 522 - 527
[4] Intracellular signal transduction of interferon on the suppression of hematopoietic progenitor cell growth.
Kamezaki, K
Kato, K
Shimoda, K
Numata, A
Haro, T
Aoki, K
Ishikawa, F
Takase, K
Ariyama, H
Matsuda, T
Miyamoto, T
Nagafuji, K
Gondo, H
Nakayama, K
Harada, M
BLOOD, 2003, 102 (11) : 167B - 167B
[5] Differential regulation of signal transduction in osteoclasts and progenitor cells.
Regmi, A
Fuson, TR
Galvin, RJS
JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 : S516 - S516
[6] CXCR4-linked signal transduction in the development of human hematopoietic progenitor cells
Vichalkovski, A
Kirschner, KM
Baltensperger, K
Porzig, H
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2003, 367 : R51 - R51
[7] TRANSDUCTION AND CULTURE OF PURIFIED HEMATOPOIETIC PROGENITOR CELLS
EINERHAND, MPW
BAKX, TA
VISSER, JWM
VALERIO, D
BONE MARROW TRANSPLANTATION, 1992, 9 : 158 - 162
[8] Regulation of Cytokine Signal Transduction in Hematopoietic Stem Cells by Mammalian Target of Rapamycin
Partridge, Emily A.
Vrecenak, Jesse
Kozlowski, Miroslaw
Flake, Alan W.
BLOOD, 2012, 120 (21)
[9] Strategy of Pharmacological Regulation of Intracellular Signal Transduction in Regeneration-Competent Cells
Zyuz'kov, G. N.
Zhdanov, V. V.
Udut, E. V.
Miroshnichenko, L. A.
Polyakova, T. Yu.
Stavrova, L. A.
Udut, V. V.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2019, 166 (04) : 448 - 455
[10] Strategy of Pharmacological Regulation of Intracellular Signal Transduction in Regeneration-Competent Cells
G. N. Zyuz’kov
V. V. Zhdanov
E. V. Udut
L. A. Miroshnichenko
T. Yu. Polyakova
L. A. Stavrova
V. V. Udut
Bulletin of Experimental Biology and Medicine, 2019, 166 : 448 - 455

← 1 2 3 4 5 →