Tumour microenvironment-responsive semiconducting polymer-based self-assembling nanotheranostics

被引：0

作者：

Yang, Zhen ^{[1
,2
]}

Dai, Yunlu ^{[3
]}

Shan, Lingling ^{[2
]}

Shen, Zheyu ^{[2
]}

Wang, Zhantong ^{[2
]}

Yung, Bryant C. ^{[2
]}

Jacobson, Orit ^{[2
]}

Liu, Yijing ^{[2
]}

Tang, Wei ^{[2
]}

Wang, Sheng ^{[2
]}

Lin, Lisen ^{[2
]}

Niu, Gang ^{[2
]}

Huang, Pintong ^{[1
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Ultrasound Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China

[2] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA

[3] Univ Macau, Fac Hlth Sci, Macau 999078, Peoples R China

来源：

NANOSCALE HORIZONS | 2019年 / 4卷 / 02期

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

CANCER; NANOPARTICLES; DESIGN; NANOMEDICINE; CHEMOTHERAPY; THERAPY;

D O I：

10.1039/c8nh00307f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A Pt prodrug polyphenol and gadolinium ion loaded cancer theranostics nanoplatform based on a mild acidic pH and thermal sensitive polymer was designed for photoacoustic (PA)/magnetic resonance (MR)/positron emission tomography (PET) multimodal imaging-guided chemo-photothermal combination therapy. The Pt drug release can be controlled by tumour-specific acidic pH and heat generated by external NIR irradiation. The nanoparticles were stable under normal physiological environments and released the drug under the acidic pH of tumours and NIR laser irradiation, which can reduce the side effects of the drug to normal organs. Moreover, the MR signal can be significantly enhanced (approximate to 3-fold increase in T-1 relaxivity) under the acidic tumour microenvironment, which is favorable for cancer diagnosis. The nanoparticles exhibited excellent tumour accumulation and led to complete tumour eradication with low power NIR laser irradiation. This promising approach provides a new avenue for imaging-guided combination therapy.

引用

页码：426 / 433

页数：8

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