Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica

被引：43

作者：

Greco, Raffaella ^{[1
]}

Bondanza, Attilio ^{[2
]}

Vago, Luca ^{[1
]}

Moiola, Lucia ^{[3
]}

Rossi, Paolo ^{[3
,4
]}

Furlan, Roberto ^{[3
]}

Martino, Gianvito ^{[3
]}

Radaelli, Marta ^{[3
]}

Martinelli, Vittorio ^{[3
]}

Carbone, Maria Rosaria ^{[2
]}

Stanghellini, Maria Teresa Lupo ^{[1
]}

Assanelli, Andrea ^{[1
]}

Bernardi, Massimo ^{[1
]}

Corti, Consuelo ^{[1
]}

Peccatori, Jacopo ^{[1
]}

Bonini, Chiara ^{[2
]}

Vezzulli, Paolo ^{[5
]}

Falini, Andrea ^{[5
,6
]}

Ciceri, Fabio ^{[1
]}

Comi, Giancarlo ^{[3
,6
]}

机构：

[1] Ist Sci San Raffaele, Hematol & Bone Marrow Transplantat Unit, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, Expt Hematol Unit, I-20132 Milan, Italy

[3] Ist Sci San Raffaele, Dept Neurol, I-20132 Milan, Italy

[4] Hildebrand Hosp, Dept Neurol, Brissago, Switzerland

[5] Ist Sci San Raffaele, Neuroradiol Unit, I-20132 Milan, Italy

[6] Univ Vita Salute San Raffaele, Milan, Italy

来源：

ANNALS OF NEUROLOGY | 2014年 / 75卷 / 03期

关键词：

BONE-MARROW-TRANSPLANTATION; MULTIPLE-SCLEROSIS; REPERTOIRE; GUIDELINES; TOLERANCE; SCT;

D O I：

10.1002/ana.24079

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica is a rare neurological autoimmune disorder characterized by a poor prognosis. Immunosuppression can halt disease progression, but some patients are refractory to multiple treatments, experiencing frequent relapses with accumulating disability. Here we report on durable clinical remissions after allogeneic hematopoietic stem cell transplantation in 2 patients suffering from severe forms of the disease. Immunological data evidenced disappearance of the pathogenic antibodies and regeneration of a naive immune system of donor origin. These findings correlated with evident clinical and radiological improvement in both patients, warranting extended clinical trials to investigate this promising therapeutic option. ANN NEUROL 2014;75:447-453

引用

页码：447 / 453

页数：7

共 50 条

[41] Autologous hematopoietic stem cell transplant in patients with neuromyelitis optica - four year update
Burton, J. M.
Storek, J.
Duggan, P.
Costello, F.
Bell, R.
Metz, L.
MULTIPLE SCLEROSIS JOURNAL, 2015, 21 : 79 - 79
[42] Autoimmunity Following Allogeneic Hematopoietic Stem Cell Transplantation
Buxbaum, Nataliya Prokopenko
Pavletic, Steven Z.
FRONTIERS IN IMMUNOLOGY, 2020, 11
[43] Allogeneic hematopoietic stem cell transplantation in mycosis fungoides
Atalla, Angelo
Hallack Neto, Abrahao Elias
Siqueira, Denise Bittencourt
Toledo, Gabriela Cumani
ANAIS BRASILEIROS DE DERMATOLOGIA, 2013, 88 (06) : 216 - 219
[44] Jaundice After Allogeneic Hematopoietic Stem Cell Transplantation
Mendizabal, Manuel
Chen, Terina
Reddy, K. Rajender
HEPATOLOGY, 2009, 50 (06) : 2044 - 2045
[45] Erythrocytosis after allogeneic hematopoietic stem cell transplantation
Hino, Yutaro
Doki, Noriko
Kurosawa, Shuhei
Yamamoto, Keita
Sakaguchi, Masahiro
Harada, Kaito
Ikegawa, Shuntaro
Shingai, Naoki
Hattori, Kenichiro
Senoo, Yasushi
Igarashi, Aiko
Najima, Yuho
Kobayashi, Takeshi
Kakihana, Kazuhiko
Sakamaki, Hisashi
Ohashi, Kazuteru
CLINICAL TRANSPLANTATION, 2017, 31 (04)
[46] Rhabdomyolysis After Allogeneic Hematopoietic Stem Cell Transplantation
Q. Jiang
B. H. Zhang
Indian Journal of Hematology and Blood Transfusion, 2016, 32 : 504 - 506
[47] Allogeneic hematopoietic stem-cell transplantation for myelofibrosis
Zhang, Lining
Yang, Fan
Feng, Sizhou
THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 11
[48] Hyperlipidemia After Allogeneic Hematopoietic Stem Cell Transplantation
Blaser, Bradley W.
Kim, Haesook
Plutzky, Jorge
Alyea, Edwin, III
Ho, Vincent
Cutler, Corey
Armand, Philippe
Koreth, John
Antin, Joseph H.
Soiffer, Robert
BLOOD, 2010, 116 (21) : 1419 - 1419
[49] Sequelae of pediatric allogeneic hematopoietic stem cell transplantation
Diamond, C.
Oeffinger, K.
Hall, R.
Driscoll, T.
Cardones, A.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 142 (08) : B10 - B10
[50] Polyomaviruses After Allogeneic Hematopoietic Stem Cell Transplantation
Mendoza, Maria Alejandra
Imlay, Hannah
VIRUSES-BASEL, 2025, 17 (03):

← 1 2 3 4 5 →