Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica

被引：43

作者：

Greco, Raffaella ^{[1
]}

Bondanza, Attilio ^{[2
]}

Vago, Luca ^{[1
]}

Moiola, Lucia ^{[3
]}

Rossi, Paolo ^{[3
,4
]}

Furlan, Roberto ^{[3
]}

Martino, Gianvito ^{[3
]}

Radaelli, Marta ^{[3
]}

Martinelli, Vittorio ^{[3
]}

Carbone, Maria Rosaria ^{[2
]}

Stanghellini, Maria Teresa Lupo ^{[1
]}

Assanelli, Andrea ^{[1
]}

Bernardi, Massimo ^{[1
]}

Corti, Consuelo ^{[1
]}

Peccatori, Jacopo ^{[1
]}

Bonini, Chiara ^{[2
]}

Vezzulli, Paolo ^{[5
]}

Falini, Andrea ^{[5
,6
]}

Ciceri, Fabio ^{[1
]}

Comi, Giancarlo ^{[3
,6
]}

机构：

[1] Ist Sci San Raffaele, Hematol & Bone Marrow Transplantat Unit, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, Expt Hematol Unit, I-20132 Milan, Italy

[3] Ist Sci San Raffaele, Dept Neurol, I-20132 Milan, Italy

[4] Hildebrand Hosp, Dept Neurol, Brissago, Switzerland

[5] Ist Sci San Raffaele, Neuroradiol Unit, I-20132 Milan, Italy

[6] Univ Vita Salute San Raffaele, Milan, Italy

来源：

ANNALS OF NEUROLOGY | 2014年 / 75卷 / 03期

关键词：

BONE-MARROW-TRANSPLANTATION; MULTIPLE-SCLEROSIS; REPERTOIRE; GUIDELINES; TOLERANCE; SCT;

D O I：

10.1002/ana.24079

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica is a rare neurological autoimmune disorder characterized by a poor prognosis. Immunosuppression can halt disease progression, but some patients are refractory to multiple treatments, experiencing frequent relapses with accumulating disability. Here we report on durable clinical remissions after allogeneic hematopoietic stem cell transplantation in 2 patients suffering from severe forms of the disease. Immunological data evidenced disappearance of the pathogenic antibodies and regeneration of a naive immune system of donor origin. These findings correlated with evident clinical and radiological improvement in both patients, warranting extended clinical trials to investigate this promising therapeutic option. ANN NEUROL 2014;75:447-453

引用

页码：447 / 453

页数：7

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