Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review

被引:0
|
作者
Sugunan, Sinoy [1 ]
Joseph, Diya Binoy [1 ]
Rajanikant, G. K. [1 ]
机构
[1] Natl Inst Technol Calicut, Sch Biotechnol, Calicut 673601, Kerala, India
关键词
Ischemic stroke; therapeutic targets; excitotoxicity; NADPH oxidase; inflammation; MHC-I; neuroplasticity; OXIDATIVE DNA-DAMAGE; MHC CLASS-I; POSTSYNAPTIC DENSITY PROTEINS; OCULAR-DOMINANCE PLASTICITY; BASE-EXCISION REPAIR; DEVELOPING RAT-BRAIN; SPINAL-CORD-INJURY; NOGO-A EXPRESSION; PDZ-DOMAIN; ADULT-RAT;
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.
引用
收藏
页码:497 / 506
页数:10
相关论文
共 50 条
  • [41] Non-Coding RNA in Acute Ischemic Stroke: Mechanisms, Biomarkers and Therapeutic Targets
    Wang, Sheng-Wen
    Liu, Zhong
    Shi, Zhong-Song
    CELL TRANSPLANTATION, 2018, 27 (12) : 1763 - 1777
  • [42] The role of circadian clock in astrocytes: From cellular functions to ischemic stroke therapeutic targets
    Zhang, Yuxing
    Zhao, Xin
    Zhang, Ying
    Zeng, Fukang
    Yan, Siyang
    Chen, Yao
    Li, Zhong
    Zhou, Desheng
    Liu, Lijuan
    FRONTIERS IN NEUROSCIENCE, 2022, 16
  • [43] Therapeutic management of ischemic stroke
    Priya Bindal
    Vishal Kumar
    Lakshay Kapil
    Charan Singh
    Arti Singh
    Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, 397 : 2651 - 2679
  • [44] Therapeutic Strategy for Ischemic Stroke
    Toru Yamashita
    Kentaro Deguchi
    Yoshihide Sehara
    Violeta Lukic-Panin
    Hanzhe Zhang
    Tatsushi Kamiya
    Koji Abe
    Neurochemical Research, 2009, 34 : 707 - 710
  • [45] Therapeutic Strategy for Ischemic Stroke
    Yamashita, Toru
    Deguchi, Kentaro
    Sehara, Yoshihide
    Lukic-Panin, Violeta
    Zhang, Hanzhe
    Kamiya, Tatsushi
    Abe, Koji
    NEUROCHEMICAL RESEARCH, 2009, 34 (04) : 707 - 710
  • [46] microRNA as a therapeutic for ischemic stroke
    Todoran, Raluca
    Falcione, Sarina R.
    Clarke, Michael
    Joy, Twinkle
    Boghozian, Roobina
    Jickling, Glen C.
    NEUROCHEMISTRY INTERNATIONAL, 2023, 163
  • [47] Therapeutic management of ischemic stroke
    Bindal, Priya
    Kumar, Vishal
    Kapil, Lakshay
    Singh, Charan
    Singh, Arti
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2024, 397 (05) : 2651 - 2679
  • [48] Ischemic stroke and mitochondria: mechanisms and targets
    Syed Suhail Andrabi
    Suhel Parvez
    Heena Tabassum
    Protoplasma, 2020, 257 : 335 - 343
  • [49] Ischemic stroke and mitochondria: mechanisms and targets
    Andrabi, Syed Suhail
    Parvez, Suhel
    Tabassum, Heena
    PROTOPLASMA, 2020, 257 (02) : 335 - 343
  • [50] Targets for treatment in acute ischemic stroke
    Heiss, WD
    Kracht, LW
    Thiel, A
    Grond, M
    Pawlik, G
    ANNALS OF NEUROLOGY, 2000, 48 (03) : 423 - 423