Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review

被引：0

作者：

Sugunan, Sinoy ^{[1
]}

Joseph, Diya Binoy ^{[1
]}

Rajanikant, G. K. ^{[1
]}

机构：

[1] Natl Inst Technol Calicut, Sch Biotechnol, Calicut 673601, Kerala, India

来源：

CURRENT DRUG TARGETS | 2013年 / 14卷 / 04期

关键词：

Ischemic stroke; therapeutic targets; excitotoxicity; NADPH oxidase; inflammation; MHC-I; neuroplasticity; OXIDATIVE DNA-DAMAGE; MHC CLASS-I; POSTSYNAPTIC DENSITY PROTEINS; OCULAR-DOMINANCE PLASTICITY; BASE-EXCISION REPAIR; DEVELOPING RAT-BRAIN; SPINAL-CORD-INJURY; NOGO-A EXPRESSION; PDZ-DOMAIN; ADULT-RAT;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.

引用

页码：497 / 506

页数：10

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