Locked nucleic acid: tighter is different

被引：41
|
作者：
Watts, Jonathan K. [1 ,2 ]
机构：
[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England
[2] Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 50期
关键词：
ANTISENSE OLIGONUCLEOTIDES; NUCLEOSIDE ANALOGS; LNA; RECOGNITION; RNA; DNA; STABILITY; PRIMATES; MONOMERS; DUPLEXES;
D O I：
10.1039/c3cc40340h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity and specificity of LNA, and these provide the main focus of the viewpoint.
引用
收藏
页码：5618 / 5620
页数：3
相关论文
共 50 条
  • [41] NMR solution structures of LNA (locked nucleic acid) modified quadruplexes
    Nielsen, Jakob T.
    Arar, Khalil
    Petersen, Michael
    NUCLEIC ACIDS RESEARCH, 2006, 34 (07) : 2006 - 2014
  • [42] MicroRNA detection by northern blotting using locked nucleic acid probes
    Éva Várallyay
    József Burgyán
    Zoltán Havelda
    Nature Protocols, 2008, 3 : 190 - 196
  • [43] LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides
    Hojland, Torben
    Kumar, Surender
    Babu, B. Ravindra
    Umemoto, Tadashi
    Albaek, Nanna
    Sharma, Pawan K.
    Nielsena, Poul
    Wengel, Jesper
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (15) : 2375 - 2379
  • [44] Locked nucleic acid (LNA): A modern approach to cancer diagnosis and treatment
    Kamali, Mohammad Javad
    Salehi, Mohammad
    Fatemi, Somayeh
    Moradi, Fereshteh
    Khoshghiafeh, Azin
    Ahmadifard, Mohamadreza
    EXPERIMENTAL CELL RESEARCH, 2023, 423 (01)
  • [45] Synthesis and biological properties of triazole-linked locked nucleic acid
    Sharma, Vivek K.
    Singh, Sunil K.
    Krishnamurthy, Pranathi M.
    Alterman, Julia F.
    Haraszti, Reka A.
    Khvorova, Anastasia
    Prasad, Ashok K.
    Watts, Jonathan K.
    CHEMICAL COMMUNICATIONS, 2017, 53 (63) : 8906 - 8909
  • [46] Stability and Mismatch Discrimination of Locked Nucleic Acid-DNA Duplexes
    Owczarzy, Richard
    You, Yong
    Groth, Christopher L.
    Tataurov, Andrey V.
    BIOCHEMISTRY, 2011, 50 (43) : 9352 - 9367
  • [47] Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
    Elmén, J
    Thonberg, H
    Ljungberg, K
    Frieden, M
    Westergaard, M
    Xu, YH
    Wahren, B
    Liang, ZC
    Urum, H
    Koch, T
    Wahlestedt, C
    NUCLEIC ACIDS RESEARCH, 2005, 33 (01) : 439 - 447
  • [48] MicroRNA detection by northern blotting using locked nucleic acid probes
    Varallyay, Eva
    Burgyan, Jozsef
    Havelda, Zoltan
    NATURE PROTOCOLS, 2008, 3 (02) : 190 - 196
  • [49] Applications of Locked Nucleic Acid Molecular Beacons in Molecular Recognition and Bioanalysis
    Gui Zhen
    Yan Feng
    Li Jinchang
    Ge Mengyuan
    Ju Huangxian
    PROGRESS IN CHEMISTRY, 2015, 27 (10) : 1448 - 1458
  • [50] LNA stereoisomers:: xylo-LNA (β-D-xylo configured locked nucleic acid) and α-L-LNA (α-L-ribo configured locked nucleic acid)
    Rajwanshi, VK
    Håkansson, AE
    Dahl, BM
    Wengel, J
    CHEMICAL COMMUNICATIONS, 1999, (15) : 1395 - 1396
12345