Locked nucleic acid: tighter is different

被引：41
|
作者：
Watts, Jonathan K. [1 ,2 ]
机构：
[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England
[2] Univ Southampton, Inst Life Sci, Southampton SO17 1BJ, Hants, England
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 50期
关键词：
ANTISENSE OLIGONUCLEOTIDES; NUCLEOSIDE ANALOGS; LNA; RECOGNITION; RNA; DNA; STABILITY; PRIMATES; MONOMERS; DUPLEXES;
D O I：
10.1039/c3cc40340h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity and specificity of LNA, and these provide the main focus of the viewpoint.
引用
收藏
页码：5618 / 5620
页数：3
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