Spectrally encoded photoacoustic microscopy using a digital mirror device

被引：16
|
作者：
Wang, Yu [1 ]
Maslov, Konstantin [1 ]
Wang, Lihong V. [1 ]
机构：
[1] Washington Univ, Opt Imaging Lab, Dept Biomed Engn, St Louis, MO 63130 USA
来源：
JOURNAL OF BIOMEDICAL OPTICS | 2012年 / 17卷 / 06期
基金：
美国国家卫生研究院;
关键词：
photoacoustic microscopy; spectral encoding; Hadamard encoding; digital mirror device; photoacoustic spectroscopy; wavelength multiplexing; MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY; IN-VIVO; LASER;
D O I：
10.1117/1.JBO.17.6.066020
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed spectrally encoded photoacoustic microscopy using a digital mirror device for multi-wavelength tomography, which enables fast spectral imaging of optical absorption. The optical illumination wavelengths are multiplexed at a laser pulse repetition rate of similar to 2 kHz. Liquid samples, whole blood, and blood vessels in mouse ears were imaged. Compared with internal wavelength tuning of a narrow-band laser, external wavelength tuning based on a digital mirror device improves the data acquisition speed of spectral photoacoustic microscopy. Compared with external wavelength scanning of a wide-band laser with the same pulse energy, spectral encoding improves the signal-to-noise ratio. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.6.066020]
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页数：5
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