Syntheses, structural, and biological studies of two new peptide compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetate hemihydrate and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid

被引：1
|
作者：
Hu, Mao-Lin [1 ]
Yin, Ping [1 ]
Ma, Zhi-Cheng [1 ]
Morsali, Ali [2 ]
机构：
[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China
[2] Tarbiat Modares Univ, Fac Sci, Dept Chem, Tehran 14115, Iran
来源：
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY | 2008年 / 38卷 / 11期
基金：
中国国家自然科学基金;
关键词：
2(s)-(5-fluorouracil-1-aceto)amino-2-isopropylacetate; 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid; crystal structure; thermal analysis; antitumor activity;
D O I：
10.1007/s10870-008-9396-9
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
Two new peptide compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetate hemihydrate (1:1/2H (2) O) and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid (2), have been synthesized and characterized by elemental analysis, IR, H-1- and C-13 NMR spectroscopy. Two new compounds were structurally characterized by single-crystal X-ray diffraction. The thermal stabilities of compounds 1:1/2H(2) O and 2 were studied by DSC-TGA techniques. The result of the biological test showed that the compounds 1:1/2H(2) O and 2 have certain antitumor activities.
引用
收藏
页码：807 / 813
页数：7
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