Syntheses, structural, and biological studies of two new peptide compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetate hemihydrate and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid

被引：1

作者：

Hu, Mao-Lin ^{[1
]}

Yin, Ping ^{[1
]}

Ma, Zhi-Cheng ^{[1
]}

Morsali, Ali ^{[2
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325027, Peoples R China

[2] Tarbiat Modares Univ, Fac Sci, Dept Chem, Tehran 14115, Iran

来源：

JOURNAL OF CHEMICAL CRYSTALLOGRAPHY | 2008年 / 38卷 / 11期

基金：

中国国家自然科学基金;

关键词：

2(s)-(5-fluorouracil-1-aceto)amino-2-isopropylacetate; 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid; crystal structure; thermal analysis; antitumor activity;

D O I：

10.1007/s10870-008-9396-9

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

Two new peptide compounds, 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetate hemihydrate (1:1/2H (2) O) and 2(s)-(5-fluorouracil-1-aceto)amino-2-isopropyl acetic acid (2), have been synthesized and characterized by elemental analysis, IR, H-1- and C-13 NMR spectroscopy. Two new compounds were structurally characterized by single-crystal X-ray diffraction. The thermal stabilities of compounds 1:1/2H(2) O and 2 were studied by DSC-TGA techniques. The result of the biological test showed that the compounds 1:1/2H(2) O and 2 have certain antitumor activities.

引用

页码：807 / 813

页数：7

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