[Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complex

被引：38
|
作者：
Gale, Eric M. [1 ]
Kenton, Nathaniel [1 ]
Caravan, Peter [1 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Suite 2301,149 13th St, Charlestown, MA 02129 USA
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 73期
基金：
美国国家卫生研究院;
关键词：
MRI CONTRAST AGENTS; METAL-COMPLEXES; THERMODYNAMIC STABILITY; KINETIC INERTNESS; WATER EXCHANGE; GADOLINIUM(III); PYRIDINE; LUMINESCENCE; EQUILIBRIUM; MACROCYCLE;
D O I：
10.1039/c3cc44116d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. [Gd(CyPic3A)(H2O)(2)](-) affords an r(1) value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.
引用
收藏
页码：8060 / 8062
页数：3
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