[Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complex

被引：38

作者：

Gale, Eric M. ^{[1
]}

Kenton, Nathaniel ^{[1
]}

Caravan, Peter ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Suite 2301,149 13th St, Charlestown, MA 02129 USA

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 73期

基金：

美国国家卫生研究院;

关键词：

MRI CONTRAST AGENTS; METAL-COMPLEXES; THERMODYNAMIC STABILITY; KINETIC INERTNESS; WATER EXCHANGE; GADOLINIUM(III); PYRIDINE; LUMINESCENCE; EQUILIBRIUM; MACROCYCLE;

D O I：

10.1039/c3cc44116d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. [Gd(CyPic3A)(H2O)(2)](-) affords an r(1) value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.

引用

页码：8060 / 8062

页数：3

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