Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives

被引：70

作者：

Shelke, Sharad N. ^{[2
]}

Mhaske, Ganesh R. ^{[2
]}

Bonifacio, Vasco D. B. ^{[1
]}

Gawande, Manoj B. ^{[1
]}

机构：

[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, Portugal

[2] SSGM Coll, Dept Chem, Kopargaon 423601, MH, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 17期

关键词：

Green synthesis; Ultrasonic irradiation; MDR-TB; Anti-infective activity; Pyrazolines;

D O I：

10.1016/j.bmcl.2012.06.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of fluorinated pyrazoles, 4a-e, were synthesized in good to excellent overall yields (65-82%) from the corresponding chalcones, 3a-e, by ultrasonic irradiation. The newly synthesized compounds were characterized and screened for their in vitro anti-bacterial, anti-fungal, and anti-tubercular activities against Mycobacterium tuberculosis H(37)Rv. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5727 / 5730

页数：4

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