Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives

被引：70
|
作者：
Shelke, Sharad N. [2 ]
Mhaske, Ganesh R. [2 ]
Bonifacio, Vasco D. B. [1 ]
Gawande, Manoj B. [1 ]
机构：
[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE, P-2829516 Caparica, Portugal
[2] SSGM Coll, Dept Chem, Kopargaon 423601, MH, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 17期
关键词：
Green synthesis; Ultrasonic irradiation; MDR-TB; Anti-infective activity; Pyrazolines;
D O I：
10.1016/j.bmcl.2012.06.072
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new series of fluorinated pyrazoles, 4a-e, were synthesized in good to excellent overall yields (65-82%) from the corresponding chalcones, 3a-e, by ultrasonic irradiation. The newly synthesized compounds were characterized and screened for their in vitro anti-bacterial, anti-fungal, and anti-tubercular activities against Mycobacterium tuberculosis H(37)Rv. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5727 / 5730
页数：4
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