Low cytotoxicity rhodamine-based fluorescent probes for Fe(III) and their application in living cells

被引：21
|
作者：
Liu, Xiao-Jing [1 ]
Zhang, Ming [1 ]
Yang, Mei-Pan [1 ]
Li, Bo [1 ]
Cheng, Zhao [2 ]
Yang, Bing-Qin [1 ]
机构：
[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710127, Shaanxi, Peoples R China
[2] Xian Med Univ, Sch Pharmaceut Sci, Xian 710021, Shaanxi, Peoples R China
来源：
TETRAHEDRON | 2015年 / 71卷 / 42期
基金：
中国国家自然科学基金;
关键词：
Rhodamine B; Fluorescent probe; Recognition; Low toxicity; Live cell imaging; IRON; CHEMOSENSOR; FE3+; IRON(III); COUMARIN;
D O I：
10.1016/j.tet.2015.08.031
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two novel rhodamine-active probes G2 and R2 were designed and synthesized, which adopted a 1:1 binding stoichiometry and showed highly selective sensing for Fe3+ ions over other metal ions in EtOH-H2O (1:1, v/v, Tris-HCl pH=7.4) in the fluorescence and ultraviolet spectra. Cytotoxicity and bioimaging studies by PC12 and L929 indicated that the probes were low cytotoxic, cell permeable and suitable for detecting Fe3+ in living cells. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8194 / 8199
页数：6
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