Defining the molecular blueprint that drives CD8+ T cell differentiation in response to infection

被引：15

作者：

Russ, Brendan E. ^{[1
]}

Denton, Alice E. ^{[2
]}

Hatton, Lauren ^{[1
]}

Croom, Hayley ^{[1
]}

Olson, Matthew R. ^{[1
]}

Turner, Stephen J. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Univ Cambridge, Cambridge Res Inst, Dept Med, Cambridge, England

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

关键词：

cytotoxic T cells; memory T cells; transcription factors; epigenetics; histone modifications; TRANSCRIPTION FACTOR; EFFECTOR FUNCTION; CUTTING EDGE; CHROMATIN SIGNATURES; EARLY ESTABLISHMENT; RECALL RESPONSES; CLONAL EXPANSION; DENDRITIC CELLS; RNA-POLYMERASE; CENTRAL MEMORY;

D O I：

10.3389/fimmu.2012.00371

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naive CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.

引用

页数：11

共 50 条

[41] One naive T cell, multiple fates in CD8+ T cell differentiation
Gerlach, Carmen
van Heijst, Jeroen W. J.
Swart, Erwin
Sie, Daoud
Armstrong, Nicola
Kerkhoven, Ron M.
Zehn, Dietmar
Bevan, Michael J.
Schepers, Koen
Schumacher, Ton N. M.
JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (06): : 1235 - 1246
[42] Teucrium montanum extract drives effector and memory differentiation of CD8+ T cells
Li, Jing J.
Ma, Shuanggang
Wang, Yaling
Wang, Manqiu
Li, Mingyan
Gao, Changxing
Zhang, Lingzhi
Li, Yong
Liu, Yunbao
Stevanovic, Zora Dajic
Tanic, Nikola
Arsenijevic, Nebojsa
Yu, Shishan
Zhu, Qing
BIOMEDICAL RESEARCH AND THERAPY, 2023, 10 (11): : 6023 - 6034
[43] CD8+ T cell effector mechanisms in resistance to infection
Harty, JT
Tvinnereim, AR
White, DW
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 : 275 - 308
[44] T-bet-mediated differentiation of the activated CD8+ T cell
Yeo, Crystal J. J.
Fearon, Douglas T.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (01) : 60 - 66
[45] Defining Kinetic Properties of HIV-Specific CD8+ T-Cell Responses in Acute Infection
Yang, Yiding
Ganusov, Vitaly V.
MICROORGANISMS, 2019, 7 (03)
[46] Molecular mechanisms of CD8+ T cell trafficking and localization
Jeffrey C. Nolz
Cellular and Molecular Life Sciences, 2015, 72 : 2461 - 2473
[47] Molecular mechanisms of CD8+ T cell trafficking and localization
Nolz, Jeffrey C.
CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 72 (13) : 2461 - 2473
[48] Molecular Dissection of CD8+ T-Cell Dysfunction
Wang, Chao
Singer, Meromit
Anderson, Ana C.
TRENDS IN IMMUNOLOGY, 2017, 38 (08) : 567 - 576
[49] A central role for Notch in effector CD8+ T cell differentiation
Ronald A Backer
Christina Helbig
Rebecca Gentek
Andrew Kent
Brian J Laidlaw
Claudia X Dominguez
Yevan S de Souza
Stella E van Trierum
Ruud van Beek
Guus F Rimmelzwaan
Anja ten Brinke
A Marcel Willemsen
Antoine H C van Kampen
Susan M Kaech
J Magarian Blander
Klaas van Gisbergen
Derk Amsen
Nature Immunology, 2014, 15 : 1143 - 1151
[50] CD8+ thymocyte differentiation: T cell two-step
Nicholas R J Gascoigne
Nature Immunology, 2010, 11 : 189 - 190

← 1 2 3 4 5 →