Defining the molecular blueprint that drives CD8+ T cell differentiation in response to infection

被引：15

作者：

Russ, Brendan E. ^{[1
]}

Denton, Alice E. ^{[2
]}

Hatton, Lauren ^{[1
]}

Croom, Hayley ^{[1
]}

Olson, Matthew R. ^{[1
]}

Turner, Stephen J. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Univ Cambridge, Cambridge Res Inst, Dept Med, Cambridge, England

来源：

FRONTIERS IN IMMUNOLOGY | 2012年 / 3卷

关键词：

cytotoxic T cells; memory T cells; transcription factors; epigenetics; histone modifications; TRANSCRIPTION FACTOR; EFFECTOR FUNCTION; CUTTING EDGE; CHROMATIN SIGNATURES; EARLY ESTABLISHMENT; RECALL RESPONSES; CLONAL EXPANSION; DENDRITIC CELLS; RNA-POLYMERASE; CENTRAL MEMORY;

D O I：

10.3389/fimmu.2012.00371

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naive CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.

引用

页数：11

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