Thrombin cleavage at Arg1689 influences heavy chain cleavage during activation of factor VIII

被引：0
|
作者：
Newell, J. L. [1 ]
Fay, P. J. [1 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Biochem & Biophys, Rochester, NY 14627 USA
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2009年 / 7卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
PP-MO-157
引用
收藏
页码：370 / 370
页数：1
相关论文
共 50 条
  • [41] Factor VIII A2 domain residue Asp721 facilitates thrombin-catalyzed cleavage at Arg372
    Newell, J
    Zhou, Q
    Fay, PJ
    FASEB JOURNAL, 2006, 20 (04): : A49 - A49
  • [42] A MONOCLONAL-ANTIBODY TO FACTOR-VIII INHIBITS VONWILLEBRAND-FACTOR BINDING AND THROMBIN CLEAVAGE
    PRECUP, JW
    KLINE, BC
    FASS, DN
    BLOOD, 1991, 77 (09) : 1929 - 1936
  • [43] THROMBIN CLEAVAGE ANALYSIS OF A NOVEL ANTIHAEMOPHILIC FACTOR VARIANT, FACTOR-VIII DELTA-II
    KRISHNAN, S
    KOLBE, HVJ
    LEPAGE, P
    FAURE, T
    SAUERWALD, R
    DELASALLE, H
    MULLER, C
    BIHOREAU, N
    PAOLANTONACCI, P
    ROITSCH, C
    MEULIEN, P
    PAVIRANI, A
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 195 (03): : 637 - 644
  • [44] Proteolysis at Arg740 facilitates subsequent bond cleavages during thrombin-catalyzed activation of factor VIII
    Newell, Jennifer L.
    Fay, Philip J.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (35) : 25367 - 25375
  • [45] Absence of mutations at APC cleavage sites Arg306 in factor V and Arg336, Arg562 in factor VIII in African-Americans
    Hooper, WC
    Dilley, A
    Austin, H
    Wenger, NK
    Benson, J
    Evatt, BL
    Silva, V
    Rawlins, P
    THROMBOSIS AND HAEMOSTASIS, 1998, 79 (01) : 236 - 236
  • [46] CLEAVAGE OF FACTOR-VIII LIGHT-CHAIN IS REQUIRED FOR MAXIMAL GENERATION OF FACTOR VIIIA ACTIVITY
    REGAN, LM
    FAY, PJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (15) : 8546 - 8552
  • [47] STRUCTURAL EVIDENCE THAT THE ACTIVATION PEPTIDE IS NOT RELEASED UPON THROMBIN CLEAVAGE OF FACTOR-XIII
    YEE, VC
    PEDERSEN, LC
    BISHOP, PD
    STENKAMP, RE
    TELLER, DC
    THROMBOSIS RESEARCH, 1995, 78 (05) : 389 - 397
  • [48] P3-P3′ Residues Flanking Scissile Bonds in Factor VIII Modulate Rates of Substrate Cleavage and Procofactor Activation by Thrombin
    Newell-Caito, Jennifer L.
    Griffiths, Amy E.
    Fay, Philip J.
    BIOCHEMISTRY, 2012, 51 (16) : 3451 - 3459
  • [49] DETECTION AND CHARACTERIZATION OF 2 MISSENSE MUTATIONS AT A CLEAVAGE SITE IN THE FACTOR-VIII LIGHT CHAIN
    SCHWAAB, R
    LUDWIG, M
    KOCHHAN, L
    OLDENBURG, J
    MCVEY, JH
    EGLI, H
    BRACKMANN, HH
    OLEK, K
    THROMBOSIS RESEARCH, 1991, 61 (03) : 225 - 234
  • [50] Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease
    Cao, Wenjing
    Sabatino, Denise E.
    Altynova, Ekaterina
    Lange, Amy M.
    Casina, Veronica C.
    Camire, Rodney M.
    Zheng, X. Long
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (39) : 32459 - 32466
12345