Myeloid-derived suppressor cells exert immunosuppressive function on the T helper 2 in mice infected with Echinococcus granulosus

被引：4

作者：

Zhou, Xiaojing ^{[3
,6
]}

Wang, Wen ^{[1
]}

Cui, Fang ^{[1
]}

Shi, Chunli ^{[1
]}

Gao, Xiaoping ^{[5
]}

Ouyang, Jiaxin ^{[1
]}

Wang, Yuxin ^{[3
]}

Nagai, Atsushi ^{[6
]}

Zhao, Wei ^{[1
,2
]}

Yin, Mei ^{[4
]}

Zhao, Jiaqing ^{[1
,2
]}

机构：

[1] Ningxia Med Univ, Sch Basic Med Sci, Yinchuan 750004, Ningxia, Peoples R China

[2] Ningxia Med Univ, Ctr Sci Technol, Yinchuan 750004, Ningxia, Peoples R China

[3] Ningxia Med Univ, Coll Clin Med, Yinchuan 750004, Ningxia, Peoples R China

[4] Ningxia Med Univ, Cardiovasc Hosp Cardiovasc Hosp, Gen Hosp, Yinchuan 750004, Ningxia, Peoples R China

[5] Ningxia Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Gen Hosp, Yinchuan 750004, Ningxia, Peoples R China

[6] Shimane Univ, Dept Neurol, Fac Med, Izumo, Shimane 6938501, Japan

来源：

EXPERIMENTAL PARASITOLOGY | 2020年 / 215卷

基金：

中国国家自然科学基金;

关键词：

Echinococcus granulosus; Myeloid-derived suppressor cells (MDSCs); Immunosuppressive function; CYSTIC ECHINOCOCCOSIS; RESPONSES; CYTOKINE; BALANCE;

D O I：

10.1016/j.exppara.2020.107917

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Cystic echinococcosis (CE) is a worldwide hazardous zoonotic parasitosis caused by Echinococcus granulosus. CE development involves complex immunological mechanisms, including participation of multiple immune cells and effector molecules. Myeloid-derived suppressor cells (MDSCs) are known to be involved in chronic and acute inflammatory conditions. In this study, we aimed to characterize the immune function of MDSCs in CE to improve the understanding, prevention and treatment of CE. Our results indicated that MDSCs overexpressing Ly6C and Ly6G inhibit the formation and activity of T helper 2 cells in a NO-dependent manner during E. granulosus infection.

引用

页数：8

共 50 条

[41] Cyclosporine enhances immunosuppressive functions of myeloid-derived suppressor cells in immune thrombocytopenia
Hou, Y.
Xu, M.
Feng, Q.
Yu, Y.
Liu, X.
Hou, M.
Peng, J.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2015, 13 : 26 - 26
[42] Immunosuppressive myeloid-derived suppressor cells are increased in splenocytes from cancer patients
Jordan, Kimberly R.
Kapoor, Puja
Spongberg, Eric
Tobin, Richard P.
Gao, Dexiang
Borges, Virginia F.
McCarter, Martin D.
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2017, 66 (04) : 503 - 513
[43] Myeloid-derived suppressor cells: Key immunosuppressive regulators and therapeutic targets in cancer
Li, Lingfei
Li, Mingyang
Jia, Qingge
PATHOLOGY RESEARCH AND PRACTICE, 2023, 248
[44] Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer
Ma, Jie
Xu, Huaxi
Wang, Shengjun
JOURNAL OF IMMUNOLOGY RESEARCH, 2018, 2018
[45] Regulation of suppressive function of myeloid-derived suppressor cells by CD4+ T cells
Nagaraj, Srinivas
Gabrilovich, Dmitry I.
SEMINARS IN CANCER BIOLOGY, 2012, 22 (04) : 282 - 288
[46] Modulation of T-cell function by myeloid-derived suppressor cells in hematological malignancies
Bhardwaj, Vaishali
Ansell, Stephen M. M.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
[47] Function of reactive oxygen species in myeloid-derived suppressor cells
Huang, Jiaojiao
Zhao, Yue
Zhao, Kexin
Yin, Kai
Wang, Shengjun
FRONTIERS IN IMMUNOLOGY, 2023, 14
[48] VISTA REGULATES THE DIFFERENTIATION AND FUNCTION OF MYELOID-DERIVED SUPPRESSOR CELLS
Zhang, Keman
Zekeri, Amin
Dong, Juan
Stone, Sarah
Wang, Li
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A1013 - A1013
[49] Epigenetic modifications in the accumulation and function of myeloid-derived suppressor cells
Xu, Liangjie
Zhou, Cuicui
Liang, Yi
Fan, Tinpan
Zhang, Fen
Chen, Xinxin
Yuan, Wei
FRONTIERS IN IMMUNOLOGY, 2022, 13
[50] Phenotype, development, and biological function of myeloid-derived suppressor cells
Zhao, Yang
Wu, Tingting
Shao, Steven
Shi, Bingyi
Zhao, Yong
ONCOIMMUNOLOGY, 2016, 5 (02):

← 1 2 3 4 5 →