Myeloid-derived suppressor cells exert immunosuppressive function on the T helper 2 in mice infected with Echinococcus granulosus

被引：4
|
作者：
Zhou, Xiaojing [3 ,6 ]
Wang, Wen [1 ]
Cui, Fang [1 ]
Shi, Chunli [1 ]
Gao, Xiaoping [5 ]
Ouyang, Jiaxin [1 ]
Wang, Yuxin [3 ]
Nagai, Atsushi [6 ]
Zhao, Wei [1 ,2 ]
Yin, Mei [4 ]
Zhao, Jiaqing [1 ,2 ]
机构：
[1] Ningxia Med Univ, Sch Basic Med Sci, Yinchuan 750004, Ningxia, Peoples R China
[2] Ningxia Med Univ, Ctr Sci Technol, Yinchuan 750004, Ningxia, Peoples R China
[3] Ningxia Med Univ, Coll Clin Med, Yinchuan 750004, Ningxia, Peoples R China
[4] Ningxia Med Univ, Cardiovasc Hosp Cardiovasc Hosp, Gen Hosp, Yinchuan 750004, Ningxia, Peoples R China
[5] Ningxia Med Univ, Dept Otorhinolaryngol Head & Neck Surg, Gen Hosp, Yinchuan 750004, Ningxia, Peoples R China
[6] Shimane Univ, Dept Neurol, Fac Med, Izumo, Shimane 6938501, Japan
来源：
EXPERIMENTAL PARASITOLOGY | 2020年 / 215卷
基金：
中国国家自然科学基金;
关键词：
Echinococcus granulosus; Myeloid-derived suppressor cells (MDSCs); Immunosuppressive function; CYSTIC ECHINOCOCCOSIS; RESPONSES; CYTOKINE; BALANCE;
D O I：
10.1016/j.exppara.2020.107917
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Cystic echinococcosis (CE) is a worldwide hazardous zoonotic parasitosis caused by Echinococcus granulosus. CE development involves complex immunological mechanisms, including participation of multiple immune cells and effector molecules. Myeloid-derived suppressor cells (MDSCs) are known to be involved in chronic and acute inflammatory conditions. In this study, we aimed to characterize the immune function of MDSCs in CE to improve the understanding, prevention and treatment of CE. Our results indicated that MDSCs overexpressing Ly6C and Ly6G inhibit the formation and activity of T helper 2 cells in a NO-dependent manner during E. granulosus infection.
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页数：8
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